Uterine contraction frequency during treatment of pyelonephritis in pregnancy and subsequent risk of preterm birth
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L.K. Millar
Abstract
Aims: To assess ceftriaxones effect on uterine contraction frequency and determine risk factors for subsequent preterm birth in women with pyelonephritis.
Methods: Seventy-one women with pyelonephritis at greater than 24 weeks' gestation with continuous external tocodynamometry after antibiotic administration were studied. Patients received 2 doses of ceftriaxone 1 gram intramuscularly at 24-hour intervals. Temperatures, timing of antibiotic administration, and gestational age at delivery were recorded.
Results: Uterine contraction frequency was measured for the hour prior to antibiotic administration, as well as the six hours after. Uterine activity steadily and significantly decreased from a mean of 5.1±7.3 at presentation to 2.0±2.9 uterine contractions per hour (P = .04, student t-test) six hours after ceftriaxone administration. The maximal number of contractions per hour each woman experienced did not correlate with temperature (r = .02, linear regression analysis). Uterine contractility and recurrent urinary tract infection were both associated with subsequent preterm birth (P = .004 and .016 respectively using nominal logistic regression analysis).
Conclusions: (1) A significant decrease in uterine activity from baseline occurs after ceftriaxone administration for acute pyelonephritis in pregnancy. (2) Temperature elevations are not associated with increased uterine activity. (3) Patients with significant uterine activity or recurrent urinary tract infection are at risk for preterm birth.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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- The offspring of gestational diabetes
- Matrix metalloproteinase 3 in parturition, premature rupture of the membranes, and microbial invasion of the amniotic cavity
- Levels of lipoprotein(a) in normal and compromised pregnancy
- Elevated risk for neonatal outcome following denial of pregnancy: results of a one-year prospective study compared with control groups
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- Uterine contraction frequency during treatment of pyelonephritis in pregnancy and subsequent risk of preterm birth
- Behaviour of β2-adrenoceptors on lymphocytes under continuous and pulsatile tocolysis with Fenoterol
- Maternal and fetal plasma endothelin levels in intrauterine growth restriction: relation to umbilical artery Doppler flow velocimetry
- Early markers of late-onset sepsis in premature neonates: clinical, hematological and cytokine profile
- CSF findings in neonates with seizures; infectious and noninfectious
- Viral infections in neonates with seizures
- New transcutaneous jaundice device with two optical paths
- Congress Calendar
- Roster of Perinatal Societies
- WAPM-Newsletter No 1/2003
