Cerebral hemoglobin concentration and oxygen saturation measured by intensity modulated optical spectroscopy in the human fetus during labor
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J. Chipchase
Abstract
Aims: To quantify hemoglobin concentration and oxygen saturation in the human fetal brain using intensity modulated optical spectroscopy during labor. Methods: A specially designed probe was applied to the fetal scalp in 20 women during uncomplicated labor at term. Optical fibres transmitted near infrared light to and from an intensity modulated optical spectrometer (IMOS), which detected changes in the optical parameters of the infra-red light source.Using novel offline analytic techniques, these changes were converted into absolute measurements of oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb). Summing Hb and HbO2 gives total hemoglobin concentration (HbT) and HbO2/HbT×100% provided measurements of cerebral saturation (SmcO2). Results: Of 20 fetuses studied, data from 10 fetuses were suitable for analysis. Over three consecutive uterine contractions, the mean (± SD) absolute cerebral concentrations of Hb and HbO2 were 30+/-18 and 46+/-21 μmol/l, respectively. This gave a mean cerebral HbT of 77+/-29 μmol/l and a mean SmcO2 of 59+/-12%. In the other ten fetuses insufficient light was detected to allow chromophore quantification. Conclusion: These are the first absolute measurements of cerebral Hb and HbO2 in human fetuses during labor. The values of total hemoglobin are similar to those obtained in neonates with hypoxia-ischemia and the measurements of fetal cerebral oxygen saturation are similar to previously published values. Keywords: Cerebral blood volume, fetal, intrapartum, saturation.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Author Index
- Subject Index
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- Cerebral hemoglobin concentration and oxygen saturation measured by intensity modulated optical spectroscopy in the human fetus during labor
- Growth discordance and the effect of a male twin on birth weight of its female co-twin: a population-based study
- Rhabdomyolysis during prolonged intravenous tocolytic therapy
- A rare presentation of Pompe disease with massive hypertrophic cardiomyopathy at birth
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- Congress Calendar
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Preterm premature rupture of the membranes and antioxidants: the free radical connection
- Vaginal lactobacilli and preterm birth
- Socioeconomic and environmental risk factors of bacterial vaginosis in early pregnancy
- Evaluation of creatine kinase level during long-term tocolysis
- Maternal serum glycodelin in premature rupture of membranes
- Clinical and biophysical aspects of HELLP-syndrome
- Blood flow velocity waveforms of the fetal middle cerebral artery in a normal population: reference values from 18 weeks to 42 weeks of gestation
- Cerebral hemoglobin concentration and oxygen saturation measured by intensity modulated optical spectroscopy in the human fetus during labor
- Growth discordance and the effect of a male twin on birth weight of its female co-twin: a population-based study
- Rhabdomyolysis during prolonged intravenous tocolytic therapy
- A rare presentation of Pompe disease with massive hypertrophic cardiomyopathy at birth
- Complete spontaneous resolution of severe nonimmunological hydrops fetalis with unknown etiology in the second trimester – a case report
- Epiphyseal separation of the distal humerus
- Congress Calendar
