Maternal serum glycodelin in premature rupture of membranes
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M. Loukovaara
Abstract
Aim: Few studies address decidual function in abnormal pregnancies, due obviously to shortage of appropriate markers. Glycodelin is produced by epithelial cells of pregnancy decidua. We investigated whether serum glycodelin concentrations are altered in premature rupture of membranes (PROM). Methods: Serum glycodelin concentrations were measured in 32 women with PROM and in 27 gestational age-matched healthy women. Serum C-reactive protein (CRP) concentrations were measured to indicate infection. Results: Glycodelin concentrations were similar in PROM patients and control subjects. No difference was found in glycodelin concentrations between the 17 PROM patients with CRP > 12 mg/l and controls, or between the 15 PROM patients with CRP ≤ 12 mg/l and controls. There was no correlation between the highest antepartum glycodelin level and the interval from PROM to delivery. A negative correlation between the last glycodelin concentration and the birth weight of the newborns was found in the PROM patients (rs = -0.369, p = 0.038). Conclusions: Decidual epithelial cell function does not seem to be compromised in PROM. The inverse correlation between serum glycodelin and the birth weight of the newborns in PROM may be explained by the normally occurring decline of serum glycodelin with advancing pregnancy in the third trimester.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Preterm premature rupture of the membranes and antioxidants: the free radical connection
- Vaginal lactobacilli and preterm birth
- Socioeconomic and environmental risk factors of bacterial vaginosis in early pregnancy
- Evaluation of creatine kinase level during long-term tocolysis
- Maternal serum glycodelin in premature rupture of membranes
- Clinical and biophysical aspects of HELLP-syndrome
- Blood flow velocity waveforms of the fetal middle cerebral artery in a normal population: reference values from 18 weeks to 42 weeks of gestation
- Cerebral hemoglobin concentration and oxygen saturation measured by intensity modulated optical spectroscopy in the human fetus during labor
- Growth discordance and the effect of a male twin on birth weight of its female co-twin: a population-based study
- Rhabdomyolysis during prolonged intravenous tocolytic therapy
- A rare presentation of Pompe disease with massive hypertrophic cardiomyopathy at birth
- Complete spontaneous resolution of severe nonimmunological hydrops fetalis with unknown etiology in the second trimester – a case report
- Epiphyseal separation of the distal humerus
- Congress Calendar
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Preterm premature rupture of the membranes and antioxidants: the free radical connection
- Vaginal lactobacilli and preterm birth
- Socioeconomic and environmental risk factors of bacterial vaginosis in early pregnancy
- Evaluation of creatine kinase level during long-term tocolysis
- Maternal serum glycodelin in premature rupture of membranes
- Clinical and biophysical aspects of HELLP-syndrome
- Blood flow velocity waveforms of the fetal middle cerebral artery in a normal population: reference values from 18 weeks to 42 weeks of gestation
- Cerebral hemoglobin concentration and oxygen saturation measured by intensity modulated optical spectroscopy in the human fetus during labor
- Growth discordance and the effect of a male twin on birth weight of its female co-twin: a population-based study
- Rhabdomyolysis during prolonged intravenous tocolytic therapy
- A rare presentation of Pompe disease with massive hypertrophic cardiomyopathy at birth
- Complete spontaneous resolution of severe nonimmunological hydrops fetalis with unknown etiology in the second trimester – a case report
- Epiphyseal separation of the distal humerus
- Congress Calendar
