Evaluation of creatine kinase level during long-term tocolysis
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Y. Matsuda
Abstract
Objective: This study was performed to evaluate serum creatine kinase (CK) levels during tocolytic therapy. Methods: A retrospective study was performed in 27 patients who were treated with intravenous tocolytic agents for more than one week. The first-line tocolytic agent was ritodrine hydrochloride, followed by concomitant magnesium sulfate (MgSO4). The serum CK level was measured on admission and every week thereafter. The patients were divided into the normal CK (group 1) and abnormal CK (> 150 IU/L) (group 2) groups. Results: Seventeen patients received both ritodrine hydrochloride and MgSO4. The CK levels in all patients rose significantly from 58.4 ± 30.8 IU/L on admission 116.0 ± 68.7 IU/L on day 7 (p = 0.002). Abnormal elevation of CK occurred in 7 (25.9%) of the 27 patients. Significant differences were found between groups 1 and 2 in the total doses of ritodrine and MgSO4 (p = 0.046 and 0.0028, respectively). All patients in group 2 received ritodrine in combination with MgSO4 (p = 0.018). Conclusion: When tocolytic therapy continued for more than 1 week, nearly one-fourth of patients showed an increase in CK level above the normal range.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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- Author Index
- Subject Index
- Contents
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- Vaginal lactobacilli and preterm birth
- Socioeconomic and environmental risk factors of bacterial vaginosis in early pregnancy
- Evaluation of creatine kinase level during long-term tocolysis
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- Growth discordance and the effect of a male twin on birth weight of its female co-twin: a population-based study
- Rhabdomyolysis during prolonged intravenous tocolytic therapy
- A rare presentation of Pompe disease with massive hypertrophic cardiomyopathy at birth
- Complete spontaneous resolution of severe nonimmunological hydrops fetalis with unknown etiology in the second trimester – a case report
- Epiphyseal separation of the distal humerus
- Congress Calendar
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Preterm premature rupture of the membranes and antioxidants: the free radical connection
- Vaginal lactobacilli and preterm birth
- Socioeconomic and environmental risk factors of bacterial vaginosis in early pregnancy
- Evaluation of creatine kinase level during long-term tocolysis
- Maternal serum glycodelin in premature rupture of membranes
- Clinical and biophysical aspects of HELLP-syndrome
- Blood flow velocity waveforms of the fetal middle cerebral artery in a normal population: reference values from 18 weeks to 42 weeks of gestation
- Cerebral hemoglobin concentration and oxygen saturation measured by intensity modulated optical spectroscopy in the human fetus during labor
- Growth discordance and the effect of a male twin on birth weight of its female co-twin: a population-based study
- Rhabdomyolysis during prolonged intravenous tocolytic therapy
- A rare presentation of Pompe disease with massive hypertrophic cardiomyopathy at birth
- Complete spontaneous resolution of severe nonimmunological hydrops fetalis with unknown etiology in the second trimester – a case report
- Epiphyseal separation of the distal humerus
- Congress Calendar
