Neuropathological features of the brain in acardius acormus
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M. Morizane
Abstract
Acardia is the most severe complication in monozygotic twinning. Acardius acormus is an uncommon phenotype among acardias. We report on an acardius acormus using thorough gross and light microscopic examination of the brain. Neuropathological examination revealed a severely disorganized cerebral cortex, agenesis of cerebellum and brain stem, and undeveloped basal ganglia and thalamus. In particular, the cerebral cortex was characterized by no clear lamination, almost complete loss of neurons, extensive gliosis, angiogenesis and focal mineralization. Neurohistology of the acardius acormus clearly demonstrated two types of lesions: developmental arrest of the brain and hypoxic-asphyxic damage to the brain with reactive gliosis and angiogenesis. Both types of lesions may be induced by the same teratogen: early onset of persisting hypoxia due to a reversed arterial perfusion. The quality of the description contributes valuably to a better understanding of the basic mechanism underlying the acardius phenotype.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Cutaneous and subcutaneous infections in newborns due to anaerobic bacteria
- Repeated prenatal corticosteroids reduce glial fibrillary acidic protein in the ovine central nervous system
- Are intrapartum and neonatal deaths in breech delivery at term potentially avoidable? – A blinded controlled audit
- A comparison of clinical variables that predict adverse outcome in term infants with severe respiratory failure randomised to a policy of extracorporeal membrane oxygenation or to conventional neonatal intensive care
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- The midwife factor in obstetric procedures and neonatal outcome
- Cerebral intracellular calcium concentrations in asphyxiated rat fetuses resuscitated with oxygen
- V-shaped deceleration differs in the pattern of carotid blood flow from variable deceleration provoked by cord compression
- Sudden intractable respiratory failure in extremely low birth weight infants with H-type tracheoesophageal fistula
- Neuropathological features of the brain in acardius acormus
- Transient postpartum diabetes insipidus in twin pregnancy associated with HELLP syndrome
- Congress Calendar
- WAPM-Newsletter No 1/2002
