Effects of selective inhibition of the Endothelin A and B receptors on hypoxic pulmonary vasoconstriction in newborn piglets
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Sverre Medbø
Abstract
The effects on pulmonary artery pressure (PAP) and plasma Endothelin-1 (ET-1) were studied in piglets during severe hypoxemia and reoxygenation for 2 h with selective inhibition of the endothelin receptors. Two groups were subjected to selective ETA (ETA group) or ETB (ETB group) receptor inhibition. During hypoxemia there was an initial increase in PAP to 36.3 and 34.3 mm Hg in the ETA and ETB groups respectively, with a decrease to the end of hypoxemia. During reoxygenation PAP reached a maximum at 5 min with a mean of 29.6 and 38.4 mm Hg in the ETA and ETB groups respectively, and then PAP gradually declined towards baseline. During the 2 h reoxygenation period PAP was higher in the ETB group than in the ETA group (p = 0.02). Plasma ET-1 increased from 1.50 and 1.17 ng/L at baseline to 2.07 and 3.18 ng/L at the end of hypoxemia in the ETA and ETB groups respectively. Conclusion: ETB receptor inhibition leads to increased pulmonary vasoconstriction during reoxygenation following hypoxemia compared to ETA receptor inhibition. Not only the ETB receptor, but also the ETA receptor plays a role in maintaining plasma ET-1 levels.
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- The first 40 years – a subjective review
- The effect of postnatal steroids on growth and development
- Mild maternal undernutrition in the first half of ovine pregnancy influences placental morphology but not fetal Doppler flow velocity waveforms and fetal heart size
- Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy
- Women’s perceptions and experiences of childbirth in United Arab Emirates
- A role for the 72 kDa gelatinase (MMP-2) and its inhibitor (TIMP-2) in human parturition, premature rupture of membranes and intraamniotic infection
- The value of ultrasonographic examination of the uterine cervix in predicting post-term pregnancy
- Maternal complications associated with cesarean section
- Patent ductus arteriosus in very low birthweight infants: complications of pharmacological and surgical treatment
- Bedside functional imaging of the premature infant brain during passive motor activation
- Effects of selective inhibition of the Endothelin A and B receptors on hypoxic pulmonary vasoconstriction in newborn piglets
- Surfactant lavage and replacement in meconium aspiration syndrome with pulmonary hemorrhage
- Gelastic seizures in clusters in a case of West syndrome after perinatal hypothalamic hemorrhage
- Fetal pulse oximetry is a safe method during high-risk delivery
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