Extracellular matrix components of the wall of umbilical cord vein and their alterations in pre-eclampsia
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Lech Romanowicz
Abstract
Pre-eclampsia — edema, proteinuria, hypertension (EPH-gestosis) is one of the more common complications observed during pregnancy. The umbilical cord vein walls were taken from newborns delivered by healthy mothers (control material) and by mothers with polysymptomatic pre-eclampsia (investigated material). Normal saphenous vein walls were collected from adult subjects undergoing varicose vein surgery. The collagen content was measured by the assay of hydroxyproline. Elastin was determined according to Fastin Elastin Assay and gravimetrically. Glycosaminoglycans content was determined by uronic acids assay. The collagen content decreased in the pre-eclampsia material. The amount of soluble elastin increased in the investigated material. The insoluble elastin content decreased in the umbilical cord veins of newborns delivered by mothers with pre-eclampsia. Reconstructing the umbilical cord vein wall may disturb fetal blood flow and affect the vascular system in adulthood.
Copyright (c)2000 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Fetal venous circulation - an update on hemodynamics
- Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns
- Risk factors for intraventricular hemorrhage in a birth cohort of 3721 premature infants
- Choice of cesarean section and perception of legal pressure
- Detection of C-type natriuretic peptide in fetal circulation
- Evaluation of a strategy to limit blood donor exposure in high risk premature newborns based on clinical estimation of transfusion need
- The significance of interleukin-6 concentrations in cervicovaginal fluid: its relation to umbilical cord plasma and the influence of antibiotic treatment
- Maternal serum interleukin 6 levels in preterm labor: prediction of admission-to-delivery interval
- Extracellular matrix components of the wall of umbilical cord vein and their alterations in pre-eclampsia
- Legionnaires disease complicating pregnancy: a case report with intrauterine fetal demise
- Intrauterine MRI with single-shot fast-spin echo imaging showed different signal intensities in hypoplastic lungs
- Congenital lobar emphysema occurring in twins
- Fetal intrathoracic injuries following mild maternal motor vehicle accident
