1H NMR as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus
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Phyllis E. McGowan
Abstract
Ten amniotic fluid samples obtained from third trimester pregnant women suffering from insulin dependant diabetes mellitus were analysed by 1H-NMR and compared to ten samples from a group of normal volunteers. A subset of the metabolites identified; valine, lactate, alanine, acetate, citrate and glucose were quantitated using standard addition methods. Apart from valine and citrate, a general diminution in the concentration of each of these species was found, especially glucose, in the diabetic group. The abnormally low glucose levels in the diabetic group are suggestive of infection in the patient group. However, the depressed lactate levels in the diabetic group suggest that in these cases the fetus was not subjected to stress.
Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Cord occlusion techniques for selective termination in monochorionic twins
- Comparison of vaginal and cesarean section delivery for fetuses in breech presentation
- Neonatal cerebral Doppler: Arterial and venous flow velocity measurements using color and pulsed Doppler system
- MMP/TIMP imbalance in amniotic fluid during PROM: an indirect support for endogenous pathway to membrane rupture
- Pulmonary hemorrhage in neonates of early and late gestation
- Nucleated red blood cells in cord blood of singleton term and post-term neonates
- Neonatal lung function in very immature infants with and without RDS
- Doppler sonographic findings for hypertension in pregnancy and HELLP syndrome
- Vitamin E status of infants at birth
- Successful transcutaneous arterial embolization of a giant hemangioma associated with high-output cardiac failure and Kasabach-Merritt syndrome in a neonate: A case report
- 1H NMR as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus
