The sensitivity of the trivariate analysis using maternal serum alpha-feto protein, human chorionic gonadotrophin and maternal age in screening for fetal aneuploidy in mothers above the age of 35
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C. Anandakumar
Abstract
This study was undertaken to assess the usefulness of maternal serum human chorionic gonadotrophin, alphafetoprotein and maternal age in screening for fetuses with abnormal chromosomes in pregnant women aged 35 years and over.
From 1989 to 1991, 1208 women seen at the National University Hospital had karyotyping procedures performed for maternal age > 35 years as well as second trimester serum samples taken for alpha-fetoprotein and human chorionic gonadotrophin. Sixteen (1.3%) chromosomal abnormalities were present. Using cut off risk levels of 1:250 and 1:384, the sensitivity of the analysis in screening for Down's syndrome pregnancies was 71.5% and 86% respectively. For the non Down's chromosomal abnormalities, using cut off risk levels of 1:250 and 1:384, the sensitivity of the analysis was only 22.3% and 33.4% respectively. Thus risk calculations based on the two serum markers and maternal age failed to identify all fetuses with abnormal chromosomes.
Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- The study of morphology and circulation of early embryo by three-dimensional ultrasound and power Doppler
- The merit of routine cord blood pH measurement at birth
- The influence of maternal erythrocyte deformability on fetal growth, gestational age and birthweight
- Reproductive choice in individuals HIV-1 infected in South Eastern Italy
- The sensitivity of the trivariate analysis using maternal serum alpha-feto protein, human chorionic gonadotrophin and maternal age in screening for fetal aneuploidy in mothers above the age of 35
- Neonatal and pediatric outcome of infants born to mothers with Antiphospholipid Syndrome
- Changes in cervical resistance and collagen fluorescence during gestation in rats
- The study of maternal and fetal plasma catecholamines levels during pregnancy and delivery
- Is adolescent pregnancy associated with adverse perinatal outcome?
- Physical exercise during pregnancy - physiological considerations and recommendations
- Endothelin-1 levels in infants with pulmonary hypertension receiving extracorporeal membrane oxygenation
- Maternal and neonatal outcome of twin pregnancies complicated by single fetal death
- A fatal case of congenital disseminated langerhans cell histiocytosis
- Treatment of severe postpartum hemorrhage by rectally administered gemeprost pessaries
