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Entropy Generation at the Cellular Level during Freezing Process of Biological Materials

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Published/Copyright: January 12, 2009
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Journal of Non-Equilibrium Thermodynamics
From the journal Volume 33 Issue 4

Abstract

In this paper, we propose using entropy generation theory to interpret and assess a single cell's freezing injury resulting from the irreversible thermodynamic process of heat and mass transfer throughout the cell. Correspondingly, heat and mass transport and entropy generation models at the cellular level were established. Several typical freezing processes of biological cells were investigated by comparing the variation of total cell entropy generation before and after freezing, which could well reflect the cell freezing injury. The simulation accords well with existing experimental results. With the entropy generation theory, it is possible to predetermine the suitable freezing protocol and thus to minimize the freeze injury while assuring the maximum vitality of the cell. Furthermore, an evaluation of cell injury induced by different freezing combinations could be easily performed by taking advantage of the present model. This study helps to better understand the physical-chemical processes during cell freezing. It also suggests a novel way to effectively optimize freezing protocols as well as to evaluate the damage degree involved.

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Received: 2008-03-18
Accepted: 2008-07-18
Published Online: 2009-01-12
Published in Print: 2008-December

© 2008 Walter de Gruyter · Berlin · New York

Articles in the same Issue

  1. Acknowledgement
  2. Contents of Volume 33 (2008)
  3. Index of Authors
  4. Analytical Subject Index Volume 33
  5. Irreversible Jaynes Engine for More Efficient Heating
  6. Entropy Generation at the Cellular Level during Freezing Process of Biological Materials
  7. An Outlook on Biothermodynamics: Needs, Problems, and New Developments. I. Stability and Hydration of Proteins
  8. Erratum to the article “A Finite-Time Thermodynamics of Unsteady Fluid Flows”
  9. Erratum to the Author Index Volume 32 (2007)
https://doi.org/10.1515/JNETDY.2008.014

Articles in the same Issue

  1. Acknowledgement
  2. Contents of Volume 33 (2008)
  3. Index of Authors
  4. Analytical Subject Index Volume 33
  5. Irreversible Jaynes Engine for More Efficient Heating
  6. Entropy Generation at the Cellular Level during Freezing Process of Biological Materials
  7. An Outlook on Biothermodynamics: Needs, Problems, and New Developments. I. Stability and Hydration of Proteins
  8. Erratum to the article “A Finite-Time Thermodynamics of Unsteady Fluid Flows”
  9. Erratum to the Author Index Volume 32 (2007)
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