Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds
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Rekha Raghuveer Shenoy
Abstract
Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally inflicted wounds in rats.
Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University.
Results: Morin showed significant wound contraction on day 7 as compared to control with mean closure of 47.44±6.07% in excision wound model. Granulation tissue breaking strength was significantly increased (p<0.05) in the morin treated group with 180.2±7.94 g when compared to control at 151.2±6.99 g. There was a significant increase in hydroxyproline content with the morin treated group when compared to control with 3.41±0.33 μg/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing.
Conclusions: Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.
©2011 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Left anterior descending/right coronary artery as culprit arteries in acute myocardial infarction (n=2011) in changing physical environment, percutaneous coronary intervention data, 2000–2010
- Changes in ECG pattern with advancing age
- The effects of docosahexaenoic acid supplementation and exercise on growth hormone and insulin-like growth factor I serum levels during chronic hypoxia in rats
- Evaluation of antidepressant activity of ropinirole coadministered with fluoxetine in acute and chronic behavioral models of depression in rats
- The effect of cypermethrin on different tissues of freshwater fish Tilapia mossambica (Perters)
- In vitro antibacterial activity of nanoconjugated vancomycin against plasmid mediated intraspecies and interspecies transfer of vancomycin resistance
- Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds
- Effects of nimesulide on testicular functions in prepubertal albino rats
- Prescription pattern of antidiabetic drugs in the outpatient departments of hospitals in Malappuram District, Kerala
