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Induced testosterone deficiency: from clinical presentation of fatigue, erectile dysfunction and muscle atrophy to insulin resistance and diabetes
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George Yu
Published/Copyright:
October 1, 2011
Abstract
Over the past 60 years, androgen deprivation therapy has been the mainstay of treatment of metastatic prostate cancer. However, research findings suggest that androgen deprivation therapy inflicts serious adverse effects on overall health and reduces the quality of life. Among the adverse effects known to date are insulin resistance, diabetes, metabolic syndrome fatigue, erectile dysfunction, and cardiovascular disease. In this clinical perspective, we discuss the relationship between induced androgen deficiency and a host of pathologies in the course of treatment with androgen deprivation therapy for prostate cancer patients.
Keywords: androgen deprivation therapy; fatigue; insulin resistance; mitochondria; mitochondrial dysfunction; testosterone; testosterone deficiency; type 2 diabetes
Received: 2011-10-11
Accepted: 2011-11-18
Published Online: 2011-10-01
Published in Print: 2011-10-01
©2011 by Walter de Gruyter Berlin Boston
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- Review Articles
- Induced testosterone deficiency: from clinical presentation of fatigue, erectile dysfunction and muscle atrophy to insulin resistance and diabetes
- Androgen deficiency and mitochondrial dysfunction: implications for fatigue, muscle dysfunction, insulin resistance, diabetes, and cardiovascular disease
- Original Articles
- Hydroxysteroid sulfotransferase 2B1b expression and localization in normal human brain
Keywords for this article
androgen deprivation therapy;
fatigue;
insulin resistance;
mitochondria;
mitochondrial dysfunction;
testosterone;
testosterone deficiency;
type 2 diabetes
Articles in the same Issue
- Review Articles
- Induced testosterone deficiency: from clinical presentation of fatigue, erectile dysfunction and muscle atrophy to insulin resistance and diabetes
- Androgen deficiency and mitochondrial dysfunction: implications for fatigue, muscle dysfunction, insulin resistance, diabetes, and cardiovascular disease
- Original Articles
- Hydroxysteroid sulfotransferase 2B1b expression and localization in normal human brain
