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Progesterone as a regulator of phosphorylation in the central nervous system
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Miguel A.R. Amorim
Published/Copyright:
January 21, 2011
Abstract
Progesterone exerts a variety of actions in the central nervous system under physiological and pathological conditions. As in other tissues, progesterone acts in the brain through classical progesterone receptors and through alternative mechanisms. Here, we review the role of progesterone as a regulator of kinases and phosphatases, such as extracellular-signal regulated kinases, phosphoinositide 3-kinase, Akt, glycogen synthase kinase 3, protein phosphatase 2A and phosphatase and tensin homolog deleted on chromosome 10. In addition, we analyzed the effects of progesterone on the phosphorylation of Tau, a protein that is involved in microtubule stabilization in neurons.
Keywords: Akt; dihydroprogesterone; extracellular-signal regulated kinases; glycogen synthase kinase 3; phosphatase and tensin homolog deleted on chromosome 10; phosphoinositide 3-kinase; protein phosphatase 2A; PTEN; Tau; tetrahydroprogesterone
Received: 2010-10-4
Accepted: 2010-10-5
Published Online: 2011-01-21
Published in Print: 2010-12-01
©2010 by Walter de Gruyter Berlin New York
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- Hormones in normal and pathological pregnancies
- The distribution of placental oxidoreductase isoforms provides different milieus of steroids influencing pregnancy in the maternal and fetal compartment
- Hormones and the brain and related diseases (e.g.: Alzheimer's, dementia)
- Progesterone as a regulator of phosphorylation in the central nervous system
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Articles in the same Issue
- Hormones in normal and pathological pregnancies
- The distribution of placental oxidoreductase isoforms provides different milieus of steroids influencing pregnancy in the maternal and fetal compartment
- Hormones and the brain and related diseases (e.g.: Alzheimer's, dementia)
- Progesterone as a regulator of phosphorylation in the central nervous system
- Estrogens and progestins: molecular effects on brain cells
