Artikel
Lizenziert
Nicht lizenziert
Erfordert eine Authentifizierung
Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma
-
Shusai Yamada
,
Rie Tabata
Veröffentlicht/Copyright:
22. Juni 2011
Abstract
Background: Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin associated with asbestos exposure. MPM has a limited response to conventional chemotherapy and radiotherapy, so early diagnosis of MPM is very important. This study investigated the pleural effusion mesothelin levels in patients with MPM and compared them to those of a population with a non-malignant pleuritis or lung cancer involving malignant pleural effusion.
Methods: The pleural effusion mesothelin concentrations were measured in 45 MPM patients and 53 non-MPM individuals (24 individuals with non-malignant pleural effusions and 29 individuals with lung cancer involving malignant pleural effusion).
Results: This study demonstrated that patients with MPM had significantly higher pleural effusion mesothelin levels than a population with non-malignant pleuritis or lung cancer involving malignant pleural effusion. The difference in overall survival between the groups with pleural effusion mesothelin levels lower and higher than the assumed cut-off of 10 nM was significant.
Conclusions: The data suggest that the pleural effusion mesothelin concentration could be useful as an aid for the diagnosis of MPM.
Received: 2010-12-17
Accepted: 2011-5-20
Published Online: 2011-06-22
Published in Print: 2011-10-01
©2011 by Walter de Gruyter Berlin Boston
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Artikel in diesem Heft
- Editorial
- Laboratory medicine: an essential partner in the care of cancer patients
- Reviews
- Circulating tumor cells as emerging tumor biomarkers in breast cancer
- Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer
- Increased plasma concentrations of tumour markers in the absence of neoplasia
- Recent progress and clinical importance on pharmacogenetics in cancer therapy
- Genetics and Molecular Diagnostics
- Genotyping of the hemochromatosis HFE p.H63D and p.C282Y mutations by high-resolution melting with the Rotor-Gene 6000® instrument
- General Clinical Chemistry and Laboratory Medicine
- Mapping point-of-care performance using locally-smoothed median and maximum absolute difference curves
- The use of inflammatory markers as a method for discharging patients post hip or knee arthroplasty
- Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease
- Combined effects of coffee consumption and serum γ-glutamyltransferase on serum C-reactive protein in middle-aged and elderly Japanese men and women
- Multicentre comparison of free thyroid hormones immunoassays: the Immunocheck study
- Comparative evaluation of capillary zone electrophoresis and HPLC in the determination of carbohydrate-deficient transferrin
- Determinants of blood levels of some thrombogenic biomarkers in healthy Arab adolescent subjects
- Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples
- Diagnostic utility of a soluble cytokeratin 18 assay for gastrointestinal graft-vs.-host disease detection
- Cancer Diagnostics
- The correlation between zinc and insulin-like growth factor 1 (IGF-1), its binding protein (IGFBP-3) and prostate-specific antigen (PSA) in prostate cancer
- Differential expression of CDC25 phosphatases splice variants in human breast cancer cells
- Serum APRIL, a potential tumor marker in pancreatic cancer
- Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma
- Infectious Diseases
- New serum biomarkers for detection of tuberculosis using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry
- Cardiovascular Diseases
- Association of a functional polymorphism in the MMP7 gene promoter with susceptibility to vulnerable carotid plaque in a Han Chinese Population
- Diabetes
- Glycated albumin may be a possible alternative to hemoglobin A1c in diabetic patients with anemia
- A simple micro-photometric method for urinary iodine determination
- Letters to the Editor
- Clinically needed sensitivity for very low levels of Factor XIII: not yet proven for a new functional assay
- Apolipoprotein A5-12238 T>C gene polymorphism and risk factors for metabolic syndrome in the Guo Shan Yao and the Han populations
- Congress Abstracts
- 10.1515/CCLM.2011.738
- 1st National Congress of Laboratory Medicine
Artikel in diesem Heft
- Editorial
- Laboratory medicine: an essential partner in the care of cancer patients
- Reviews
- Circulating tumor cells as emerging tumor biomarkers in breast cancer
- Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer
- Increased plasma concentrations of tumour markers in the absence of neoplasia
- Recent progress and clinical importance on pharmacogenetics in cancer therapy
- Genetics and Molecular Diagnostics
- Genotyping of the hemochromatosis HFE p.H63D and p.C282Y mutations by high-resolution melting with the Rotor-Gene 6000® instrument
- General Clinical Chemistry and Laboratory Medicine
- Mapping point-of-care performance using locally-smoothed median and maximum absolute difference curves
- The use of inflammatory markers as a method for discharging patients post hip or knee arthroplasty
- Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease
- Combined effects of coffee consumption and serum γ-glutamyltransferase on serum C-reactive protein in middle-aged and elderly Japanese men and women
- Multicentre comparison of free thyroid hormones immunoassays: the Immunocheck study
- Comparative evaluation of capillary zone electrophoresis and HPLC in the determination of carbohydrate-deficient transferrin
- Determinants of blood levels of some thrombogenic biomarkers in healthy Arab adolescent subjects
- Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples
- Diagnostic utility of a soluble cytokeratin 18 assay for gastrointestinal graft-vs.-host disease detection
- Cancer Diagnostics
- The correlation between zinc and insulin-like growth factor 1 (IGF-1), its binding protein (IGFBP-3) and prostate-specific antigen (PSA) in prostate cancer
- Differential expression of CDC25 phosphatases splice variants in human breast cancer cells
- Serum APRIL, a potential tumor marker in pancreatic cancer
- Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma
- Infectious Diseases
- New serum biomarkers for detection of tuberculosis using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry
- Cardiovascular Diseases
- Association of a functional polymorphism in the MMP7 gene promoter with susceptibility to vulnerable carotid plaque in a Han Chinese Population
- Diabetes
- Glycated albumin may be a possible alternative to hemoglobin A1c in diabetic patients with anemia
- A simple micro-photometric method for urinary iodine determination
- Letters to the Editor
- Clinically needed sensitivity for very low levels of Factor XIII: not yet proven for a new functional assay
- Apolipoprotein A5-12238 T>C gene polymorphism and risk factors for metabolic syndrome in the Guo Shan Yao and the Han populations
- Congress Abstracts
- 10.1515/CCLM.2011.738
- 1st National Congress of Laboratory Medicine
