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Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis
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Joerg H. Holstein
Published/Copyright:
March 26, 2010
Abstract
Background: Recent clinical and animal studies suggest that increased serum homocysteine (HCY) concentrations may be a risk factor for osteoporosis. In vitro studies showed that increasing HCY concentrations stimulate the activity of human osteoclasts. However, there is no data demonstrating that circulating HCY is related to structural and biomechanical properties of human bones. This study investigated the relationship between morphological as well as biomechanical bone properties and HCY serum concentrations in humans suffering from hip osteoarthritis (OA).
Methods: Fasting blood samples and femoral heads were obtained from 94 males and females who underwent hip arthroplasty due to OA. Bones were assessed by dual energy X-ray absorptiometry (DXA), biomechanical testing (indentation method), and histomorphometry. Blood was collected for measurement of HCY, folate, vitamin B6, and vitamin B12. Subjects were classified as hyperhomocysteinemic (>12 μmol/L, n=47) and normohomocysteinemic (<12 μmol/L, n=47) according to their serum HCY concentrations.
Results: Folate and vitamin B6, but not vitamin B12, were significantly lower in hyperhomocysteinemic subjects compared with controls. However, DXA, biomechanical testing, and histomorphometry did not reveal significant differences in bone quality between hyperhomocysteinemic subjects and controls.
Conclusions: The results of the present study do not indicate a significant relationship between circulating HCY concentrations and morphological or biomechanical bone properties in humans with OA of the hip.
Clin Chem Lab Med 2010;48:821–7.
Received: 2009-8-25
Accepted: 2010-1-15
Published Online: 2010-03-26
Published in Print: 2010-06-01
©2010 by Walter de Gruyter Berlin New York
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Keywords for this article
biomechanics;
bone mineral density;
B vitamins;
histomorphometry;
hyperhomocysteinemia
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- Biochemical markers of muscular damage
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