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Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP)
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Nele Friedrich
Published/Copyright:
November 30, 2009
Abstract
Background: The objective of the present study was to calculate age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) concentrations using quantile regression.
Methods: From the Study of Health in Pomerania (SHIP), 1798 men and women aged 25–85 years were recruited. Serum IGF-I and IGFBP-3 concentrations were determined using a chemiluminescent immunometric assay on an Immulite 2500® analyzer. Quantile regressions were performed to calculate the 2.5th and 97.5th percentiles.
Results: The reference ranges identified 43 (4.6%) women and 41 (4.8%) men with serum IGF-I concentrations, and 47 (5.0%) women and 42 (5.0%) men with serum IGFBP-3 concentrations outside the reference range.
Conclusions: The use of quantile regression results in accurate calculation of age- and gender-specific reference ranges for serum IGF-I and IGFBP-3.
Clin Chem Lab Med 2010;48:115–20.
Keywords: Immulite 2500; insulin-like growth factor I; insulin-like growth factor binding protein; quantile regression; references ranges; Study of Health in Pomerania (SHIP)
Received: 2009-6-11
Accepted: 2009-9-10
Published Online: 2009-11-30
Published in Print: 2010-01-01
©2010 by Walter de Gruyter Berlin New York
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