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Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia
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Ganesan Venkatasubramanian
Published/Copyright:
November 25, 2009
Abstract
Background: Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients.
Methods: In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed.
Results: Serum HDL had a significant inverse correlation with a total negative syndrome score (ρ=−0.43; p=0.001).
Conclusions: The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.
Clin Chem Lab Med 2010;48:95–8.
Received: 2009-7-14
Accepted: 2009-9-16
Published Online: 2009-11-25
Published in Print: 2010-01-01
©2010 by Walter de Gruyter Berlin New York
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Keywords for this article
apolipoprotein L;
high-density lipoprotein;
negative syndrome;
schizophrenia
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- Rapid diagnosis of swine-origin influenza A (H1N1) virus (S-OIV): useful or hype?
- Application of traceability concepts to analytical quality control may reconcile total error with uncertainty of measurement
- Reviews
- Pandemic influenza A (H1N1) 2009: the experience of the first six months
- The role of anti-core antibody response in the detection of occult hepatitis B virus infection
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