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The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer
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Reinhart Speeckaert
Veröffentlicht/Copyright:
4. Juni 2009
Abstract
Background: Epstein-Barr virus (EBV) is a human herpes virus that persists for life and is associated with several neoplasms. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects. The present study investigated the influence of the genetic polymorphism of Hp on EBV serology.
Methods: Patients without immunoglobulin G (IgG) titers of EBV were compared according to Hp phenotypes (Hp 1-1, Hp 2-1, Hp 2-2; determined by starch gel electrophoresis) in 208 individuals against 918 healthy subjects with unknown EBV status.
Results: The Hp 1-1 phenotype was associated with a lower EBV antibody titer (p=0.0005).
Conclusions: Our study confirms the involvement of the Hp phenotype in infection with EBV. Phenotypes with a higher Hp concentration (Hp 1-1 and Hp 2-1) are less prone to positive EBV serology.
Clin Chem Lab Med 2009;47:826–8.
Received: 2009-3-18
Accepted: 2009-4-20
Published Online: 2009-06-04
Published in Print: 2009-07-01
©2009 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
Epstein-Barr virus (EBV);
genetic polymorphism;
haptoglobin (Hp);
serology
Artikel in diesem Heft
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- Genetics and Molecular Diagnostics
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- High-sensitive microarray substrates specifically designed to improve sensitivity for the identification of fetal paternally inherited sequences in maternal plasma
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