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A polymorphism in the resistin gene promoter is related to increased C-reactive protein levels in patients with coronary artery disease
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October 31, 2007
Abstract
Background: Resistin, a novel adipocyte-derived peptide, has been linked to inflammatory process and coronary artery disease (CAD). The –420C>G polymorphism located in the resistin gene (RETN) promoter has recently been suggested to play a potential role in proinflammatory conditions (e.g., atherogenesis). However, whether this polymorphism has any effect on the inflammatory process in patients with stable CAD is unclear.
Methods: The RETN –420C>G polymorphism was determined by using PCR-restriction fragment length polymorphism. Plasma lipid profiles, glucose and high-sensitivity C-reactive protein (hs-CRP) were measured in fasting state.
Results: Patients with variant genotypes (CG+GG) had significantly higher levels of hs-CRP than CC carriers (adjusted p<0.001). In addition, the variant genotypes were observed to be independently associated with higher hs-CRP levels (>3 mg/L, p=0.004). However, no association was found between this polymorphism and plasma lipids or glucose levels.
Conclusion: Our data suggest that the RETN –420C-to-G variant is associated with increased CRP levels in patients with stable CAD, suggesting that the RETN –420C>G polymorphism may be potentially involved in the inflammatory component of atherogenesis through an enhanced production of CRP.
Clin Chem Lab Med 2007;45:1471–5.
Received: 2007-5-22
Accepted: 2007-7-10
Published Online: 2007-10-31
Published in Print: 2007-11-01
©2007 by Walter de Gruyter Berlin New York
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