Reference intervals for plasma proteins: similarities and differences between adult Caucasian and Asian Indian males in Yorkshire, UK
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A. Myron Johnson
Abstract
The aim of this study was to investigate similarities and differences in the distribution of serum concentrations of nine proteins in two racial groups (Caucasian and Asian Indian) of adult males living in the same geographical area (Leeds, Bradford, UK) for at least two generations. This is part of a larger study to determine the need for separating reference intervals for racial and ethnic groups worldwide. The distributions of concentrations for all proteins evaluated in the Indians fit ln-Gaussian distributions, indicating probable homogeneity. However, for the Caucasians, the distributions for α1-antitrypsin and possibly haptoglobin were not ln-Gaussian. In the former case, this is undoubtedly due to the number of Caucasians with lower-concentration phenotypes (Pi MS and MZ). Although haptoglobin differences may be due to genetic variants as well, this is not a complete explanation. In addition, the Indians have lower serum concentrations of orosomucoid (α1-acid glycoprotein), as has been reported by others. It is apparent that for some proteins, including α1-antitrypsin, orosomucoid, and possibly haptoglobin, the populations show differences that require the use of separate reference intervals. In addition to genetic influences, environmental differences cannot be ruled out as partial causes for some of the differences noted.
Copyright © 2004 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Editors introduction
- Reference values: from philosophy to a tool for laboratory medicine
- The evolution of the reference value concept
- Normality: the unreachable star?
- Selecting clinically relevant populations for reference intervals
- The IFCC recommendation on estimation of reference intervals. The RefVal Program
- Graphical interpretation of confidence curves in rankit plots
- Partitioning biochemical reference data intosubgroups: comparison of existing methods
- Parametric methods for estimating covariate-dependent reference limits
- Reference regions of two or more dimensions
- Should we maintain the 95 percent reference intervals in the era of wellness testing? A concept paper
- Clinical interpretation of reference intervals and reference limits. A plea for assay harmonization
- Inherent biological variation and reference values
- Intraindividual reference values
- Guideline for the production of multicentre physiological reference values using the same measurement system. A proposal of the Catalan Association for Clinical Laboratory Sciences
- Proposal for guidelines to establish common biological reference intervals in large geographical areas for biochemical quantities measured frequently in serum and plasma
- Reference intervals for plasma proteins: similarities and differences between adult Caucasian and Asian Indian males in Yorkshire, UK
- Diagnostic and epidemiological implications of regional differences in serum concentrations of proteins observed in six Asian cities
- Study of reference values and biological variation: a necessity and a model for Preventive Medicine Centers
- Creation of a low-risk reference group and referenceinterval of fasting venous plasma glucose
- Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies
- Difficulties in establishing reference intervals for special fluids: the example of 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluids
- Metrological traceability of calibration in the estimation and use of common medical decision-making criteria
- Creation of the necessary analytical quality for generating and using reference intervals
- Analytical quality specifications for common reference intervals
- Design of internal quality control for reference value studies
- The NEXUS vision: an alternative to the reference value concept
- Meetings and Awards
Articles in the same Issue
- Editors introduction
- Reference values: from philosophy to a tool for laboratory medicine
- The evolution of the reference value concept
- Normality: the unreachable star?
- Selecting clinically relevant populations for reference intervals
- The IFCC recommendation on estimation of reference intervals. The RefVal Program
- Graphical interpretation of confidence curves in rankit plots
- Partitioning biochemical reference data intosubgroups: comparison of existing methods
- Parametric methods for estimating covariate-dependent reference limits
- Reference regions of two or more dimensions
- Should we maintain the 95 percent reference intervals in the era of wellness testing? A concept paper
- Clinical interpretation of reference intervals and reference limits. A plea for assay harmonization
- Inherent biological variation and reference values
- Intraindividual reference values
- Guideline for the production of multicentre physiological reference values using the same measurement system. A proposal of the Catalan Association for Clinical Laboratory Sciences
- Proposal for guidelines to establish common biological reference intervals in large geographical areas for biochemical quantities measured frequently in serum and plasma
- Reference intervals for plasma proteins: similarities and differences between adult Caucasian and Asian Indian males in Yorkshire, UK
- Diagnostic and epidemiological implications of regional differences in serum concentrations of proteins observed in six Asian cities
- Study of reference values and biological variation: a necessity and a model for Preventive Medicine Centers
- Creation of a low-risk reference group and referenceinterval of fasting venous plasma glucose
- Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies
- Difficulties in establishing reference intervals for special fluids: the example of 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluids
- Metrological traceability of calibration in the estimation and use of common medical decision-making criteria
- Creation of the necessary analytical quality for generating and using reference intervals
- Analytical quality specifications for common reference intervals
- Design of internal quality control for reference value studies
- The NEXUS vision: an alternative to the reference value concept
- Meetings and Awards
