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Comparison of the Influence of Volume-Oriented Training and High-Intensity Interval Training on Serum Homocysteine and Its Cofactors in Young, Healthy Swimmers

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 41 Issue 11

Abstract

Background: Since homocysteine (Hcy) is a risk factor for cardiovascular and other diseases, it is important to know how exercise can modify it. Previous studies have suggested that endurance training influences Hcy. However, little is known about the effect of training intensity on Hcy. Materials and Methods: We investigated Hcy, vitamin B12, vitamin B6, folate and methylmalonic acid (MMA) before and after 3 weeks of volume-oriented training (VOL) (30 km/week) and high-intensity interval training (HIT) (20 km/week) in 20 young swimmers (16±2 years). Afterward, the athletes completed 5 days of recovery training. Results: The training induced a Hcy increase in HIT and VOL (6.47±0.95 μmol/l vs. 7.44±1.17 μmol/l and 7.33± 1.92 μmol/l vs. 8.28±1.42 μmol/l, respectively) that persisted during the recovery period (8.02±1.69 μmol/and 8.00±1.81 μmol/l, respectively). Vitamin B12 was unchanged after the training (539±166 ng/l vs. 556±192 ng/l and 480±144 ng/l vs. 491±124 ng/l, respectively) but decreased during the recovery period (459±134 ng/l and 451±116 ng/l, respectively). Folate showed an increase during the training (9.07±2.01 μg/vs. 11.71±4.08 μg/l and 10.34±2.32 μg/l vs. 11.13± 4.64 μg/l, respectively), which was reversible by the end of the recovery training (8.57±1.98 μg/l and 9.60±2.38 μg/l, respectively). Vitamin B6 and MMA did not change. For none of the measured parameters were there significant differences between HIT and VOL. Conclusion: Three weeks of strenuous swimming caused a prolonged Hcy increase, which was accompanied by changes in vitamin B12 and folate. The magnitude of these effects was not influenced by the training intensity.

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Published Online: 2005-06-01
Published in Print: 2003-11-17

Copyright © 2003 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. Where Are We Standing in Homocysteine Research?
  2. DACH-LIGA Homocystein (German, Austrian and Swiss Homocysteine Society): Consensus Paper on the Rational Clinical Use of Homocysteine, Folic Acid and B-Vitamins in Cardiovascular and Thrombotic Diseases: Guidelines and Recommendations
  3. Hyperhomocysteinaemia as a Risk Factor for Venous Thrombosis: An Update of the Current Evidence
  4. Does Homocysteine Cause Hypertension?
  5. Homocysteine Metabolism in Renal Disease
  6. Hyperhomocysteinemia and B-Vitamin Deficiencies in Infants and Children
  7. The Role of Genetic Factors in the Development of Hyperhomocysteinemia
  8. New Basis of the Neurotrophic Action of Vitamin B12
  9. Hyperhomocysteinemia and Immune Activation
  10. Interactions of Homocysteine, Nitric Oxide, Folate and Radicals in the Progressively Damaged Endothelium
  11. Influence of Hyperhomocysteinemia on the Cellular Redox State – Impact on Homocysteine-Induced Endothelial Dysfunction
  12. Homocysteine-Thiolactone and S-Nitroso-Homocysteine Mediate Incorporation of Homocysteine into Protein in Humans
  13. Association of Asymmetric Dimethylarginine and Endothelial Dysfunction
  14. Genetic Determinants of Folate and Vitamin B12 Metabolism: A Common Pathway in Neural Tube Defect and Down Syndrome?
  15. Functional Vitamin B12 Deficiency and Determination of Holotranscobalamin in Populations at Risk
  16. Holotranscobalamin as a Predictor of Vitamin B12 Status
  17. Hyperhomocysteinemia and B-Vitamin Status after Discontinuation of Oral Anticoagulation Therapy in Patients with a History of Venous Thromboembolism
  18. Measurement of Carotid Plaque and Effect of Vitamin Therapy for Total Homocysteine
  19. Folate Improves Endothelial Function in Patients with Coronary Heart Disease
  20. The Impact of Hyperhomocysteinemia as a Cardiovascular Risk Factor in the Prediction of Coronary Heart Disease
  21. Homocysteine Increases during Endurance Exercise
  22. Comparison of the Influence of Volume-Oriented Training and High-Intensity Interval Training on Serum Homocysteine and Its Cofactors in Young, Healthy Swimmers
  23. Analysis of the Transcobalamin II 776C>G (259P>R) Single Nucleotide Polymorphism by Denaturing HPLC in Healthy Elderly: Associations with Cobalamin, Homocysteine and Holo-Transcobalamin II
  24. Meetings and Awards
https://doi.org/10.1515/CCLM.2003.234

Articles in the same Issue

  1. Where Are We Standing in Homocysteine Research?
  2. DACH-LIGA Homocystein (German, Austrian and Swiss Homocysteine Society): Consensus Paper on the Rational Clinical Use of Homocysteine, Folic Acid and B-Vitamins in Cardiovascular and Thrombotic Diseases: Guidelines and Recommendations
  3. Hyperhomocysteinaemia as a Risk Factor for Venous Thrombosis: An Update of the Current Evidence
  4. Does Homocysteine Cause Hypertension?
  5. Homocysteine Metabolism in Renal Disease
  6. Hyperhomocysteinemia and B-Vitamin Deficiencies in Infants and Children
  7. The Role of Genetic Factors in the Development of Hyperhomocysteinemia
  8. New Basis of the Neurotrophic Action of Vitamin B12
  9. Hyperhomocysteinemia and Immune Activation
  10. Interactions of Homocysteine, Nitric Oxide, Folate and Radicals in the Progressively Damaged Endothelium
  11. Influence of Hyperhomocysteinemia on the Cellular Redox State – Impact on Homocysteine-Induced Endothelial Dysfunction
  12. Homocysteine-Thiolactone and S-Nitroso-Homocysteine Mediate Incorporation of Homocysteine into Protein in Humans
  13. Association of Asymmetric Dimethylarginine and Endothelial Dysfunction
  14. Genetic Determinants of Folate and Vitamin B12 Metabolism: A Common Pathway in Neural Tube Defect and Down Syndrome?
  15. Functional Vitamin B12 Deficiency and Determination of Holotranscobalamin in Populations at Risk
  16. Holotranscobalamin as a Predictor of Vitamin B12 Status
  17. Hyperhomocysteinemia and B-Vitamin Status after Discontinuation of Oral Anticoagulation Therapy in Patients with a History of Venous Thromboembolism
  18. Measurement of Carotid Plaque and Effect of Vitamin Therapy for Total Homocysteine
  19. Folate Improves Endothelial Function in Patients with Coronary Heart Disease
  20. The Impact of Hyperhomocysteinemia as a Cardiovascular Risk Factor in the Prediction of Coronary Heart Disease
  21. Homocysteine Increases during Endurance Exercise
  22. Comparison of the Influence of Volume-Oriented Training and High-Intensity Interval Training on Serum Homocysteine and Its Cofactors in Young, Healthy Swimmers
  23. Analysis of the Transcobalamin II 776C>G (259P>R) Single Nucleotide Polymorphism by Denaturing HPLC in Healthy Elderly: Associations with Cobalamin, Homocysteine and Holo-Transcobalamin II
  24. Meetings and Awards
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