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Circulating Transforming Growth Factor-β1, Lipoprotein(a) and Cellular Adhesion Molecules in Angiographically Assessed Coronary Artery Disease

  • Natasa Bogavac-Stanojevic , Srdjan Djurovic , Zorana Jelic-Ivanovic , Vesna Spasojevic- Kalimanovska and Dimitra Kalimanovska-Ostric
Published/Copyright: June 1, 2005
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 41 Issue 7

Abstract

Transforming growth factor β1 (TGF-β1) is involved in different physiological and pathological processes, including atherogenesis. High plasma lipoprotein(a) (Lp(a)) concentration is an established independent risk factor that may interfere with the plasmin-mediated TGF-β1 activation. Both Lp(a) and TGF-β1 are thought to influence the expression of cellular adhesion molecules (CAMs), also involved in the process of atherogenesis. Whereas many studies confirmed the association between high plasma Lp(a) levels and coronary artery disease (CAD), conflicting results were obtained in different studies in which the changes of TGF-β1 and CAM concentrations in CAD patients were investigated. The aim of this case-control study was to explore the association of circulating TGF-β1, Lp(a) and CAMs (intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin) levels with the occurrence and severity of angiographically assessed coronary artery disease. Plasma TGF-β1, Lp(a), ICAM-1, VCAM-1 and E-selectin concentrations were measured in 100 patients with angiographically assessed CAD and 100 healthy blood donors matched according to age and gender. Lp(a) and TGF-β1 were significantly higher in patients than in healthy controls (p < 0.001 and p < 0.01, respectively), but no significant correlation between the TGF-β1 and Lp(a) values was found. The CAM concentrations obtained in CAD patients did not differ significantly as compared with the corresponding values in the controls. None of the measured parameters were influenced by the severity of CAD.

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Published Online: 2005-06-01
Published in Print: 2003-07-21

Copyright © 2003 by Walter de Gruyter GmbH & Co. KG

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https://doi.org/10.1515/CCLM.2003.135

Articles in the same Issue

  1. 18th ICCC 2002 Kyoto
  2. Essential Hypertension: Genes and Dreams
  3. Alteration of Nucleotide Metabolism: A New Mechanism for Mitochondrial Disorders
  4. Tryptophan Metabolites and Brain Disorders
  5. The Role of Interleukin-4 and Interleukin-13 in the Non-Immunologic Aspects of Asthma Pathogenesis
  6. Soluble Guanylyl Cyclase: Physiological Role as an NO Receptor and the Potential Molecular Target for Therapeutic Application
  7. The Increasing Impact of Laboratory Medicine on Clinical Cardiology
  8. Conveying the Importance of the Preanalytical Phase
  9. Polymorphisms in the IL-4 and IL-4R [α] Genes and Allergic Asthma
  10. Circulating Transforming Growth Factor-β1, Lipoprotein(a) and Cellular Adhesion Molecules in Angiographically Assessed Coronary Artery Disease
  11. Balance of Pro- and Anti-Inflammatory Cytokines in Liver Surgery
  12. Effect of Different Dialysis Membranes on Erythrocyte Antioxidant Enzyme Levels and Scavenger Systems Related to Free Hemoglobin in Serum of Hemodialysis Patients
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  14. Determination of Itraconazole and Hydroxyitraconazole in Plasma by Use of Liquid Chromatography-Tandem Mass Spectrometry with On-line Solid-Phase Extraction
  15. High-Throughput Liquid Chromatography-Tandem Mass Spectrometric Analysis of Sirolimus in Whole Blood
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  24. State-of-the-Art Systematic Error for Biochemical Quantities with Universal Cut-off Values or Universal Reference Limits
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