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Requirements for Reproducibility, Trueness and Error of Measurement in Internal Quality Control Schemes
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Published/Copyright:
June 1, 2005
Abstract
Among the various models proposed to meet requirements for metrological performance in clinical laboratory measurements, that most widely used is intraand inter-biological variation. However, this model has weaknesses: a) in some cases, intra-individual biological variation is so small that requirements based on such data may not be met by routine methods; b) there is great variation among the intra- and inter-individual biological variations themselves. We therefore propose integration between “state-of-the-art” methods to minimize imprecision, and also suggest that requirements calculated on the basis of biological variations should be used in setting requirements for minimizing imprecision. Furthermore, we describe a new scale for setting requirements from biological variation data and suggest that systematic error should be corrected whenever it is statistically significant.
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Published Online: 2005-06-01
Published in Print: 2003-05-15
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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