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Coreceptor Usage and Biological Phenotypes of HIV-1 Isolates
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Tonie Cilliers
Published/Copyright:
June 1, 2005
Abstract
The discovery of chemokine receptors as HIV-1 entry molecules or “coreceptors” has lead to a greater understanding of how HIV-1 infects human cells. This has provided insight into the biological properties of HIV-1 isolates and unravelled the meaning of the syncytium-inducing and non-syncytium-inducing phenotypes. Understanding how HIV-1 exploits these coreceptors has given way to novel approaches to controlling HIV. As a result a new class of drugs has emerged that are being tested to prevent virus infection and to act as an alternative, or adjunct, to existing anti-retroviral drugs for HIV-infected individuals.
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Published Online: 2005-06-01
Published in Print: 2002-09-24
Copyright (c) 2002 by Walter de Gruyter GmbH & Co. KG
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