Genetic Susceptibility to Tuberculosis
-
Suneil Malik
Abstract
Tuberculosis, caused by the human pathogen Mycobacterium tuberculosis (M. tuberculosis), affects an estimated 8 million people annually, resulting in approximately 2 million deaths. Human genetic variability is an important modulator of tuberculosis susceptibility. This review will discuss candidate susceptibility genes that have been implicated in tuberculosis susceptibility across various ethnic groups and epidemiological settings. Evaluating the genetic variants of tuberculosis susceptibility genes will provide us with a better understanding of the disease mechanisms in tuberculosis. Ultimately, such genetic studies may lead to the development of effective alternative treatments to cope with the growing problem of tuberculosis infections due to the AIDS pandemic, the emergence of multidrug resistant M. tuberculosis, and the limited efficacy of Mycobacterium bovis (BCG) vaccination.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Addressing Diseases in Africa
- Tuberculosis: The Struggle Continues
- Genetic Susceptibility to Tuberculosis
- Protein Expression in Mycobacterium tuberculosis Differs with Growth Stage and Strain Type
- Molecular Detection of Early Appearance of Drug Resistance during Mycobacterium tuberculosis Infection
- Prevalence of Anti-mycolic Acid Antibodies in Patients with Pulmonary Tuberculosis Co-infected with HIV
- Reduction of the Rate of False-Positive Cultures of Mycobacterium tuberculosis in a Laboratory with a High Culture Positivity Rate
- Enhanced Immune Response in Mycobacterium bovis Bacille Calmette Guerin (BCG)-Infected IL-10-Deficient Mice
- The ELISPOT Assay: An Easily Transferable Method for Measuring Cellular Responses and Identifying T Cell Epitopes
- Coreceptor Usage and Biological Phenotypes of HIV-1 Isolates
- Overcoming Multidrug Resistance in Taxane Chemotherapy
- Accurate Microsatellite Typing and Inter-study Comparison: Pitfalls and Solutions Using Interferon-γ (IFNG) and Natural Resistance-associated Mocrophage Protein 2 (NRAMP2) Genes as Examples
- Synergism between Urinary Prothrombin Fragment 1 and Urine: A Comparison of Inhibitory Activities in Stone-Prone and Stone-Free Population Groups
- Immunoglobulin G and Subclass Responses to Plasmodium falciparum Antigens: A Study in Highly Exposed Cameroonians
- Infrequent Somatic Deletion of the 5' Region of the COL1A2 Gene in Oesophageal Squamous Cell Cancer Patients
- The Quantitative Analysis of Zearalenone and Its Derivatives in Plasma of Patients with Breast and Cervical Cancer
- Genetic Polymorphism of Cytochrome P450 1A1 (CYP1A1) and Glutathione Transferases (M1, T1 and P1) among Africans
- Meetings and Awards
Articles in the same Issue
- Addressing Diseases in Africa
- Tuberculosis: The Struggle Continues
- Genetic Susceptibility to Tuberculosis
- Protein Expression in Mycobacterium tuberculosis Differs with Growth Stage and Strain Type
- Molecular Detection of Early Appearance of Drug Resistance during Mycobacterium tuberculosis Infection
- Prevalence of Anti-mycolic Acid Antibodies in Patients with Pulmonary Tuberculosis Co-infected with HIV
- Reduction of the Rate of False-Positive Cultures of Mycobacterium tuberculosis in a Laboratory with a High Culture Positivity Rate
- Enhanced Immune Response in Mycobacterium bovis Bacille Calmette Guerin (BCG)-Infected IL-10-Deficient Mice
- The ELISPOT Assay: An Easily Transferable Method for Measuring Cellular Responses and Identifying T Cell Epitopes
- Coreceptor Usage and Biological Phenotypes of HIV-1 Isolates
- Overcoming Multidrug Resistance in Taxane Chemotherapy
- Accurate Microsatellite Typing and Inter-study Comparison: Pitfalls and Solutions Using Interferon-γ (IFNG) and Natural Resistance-associated Mocrophage Protein 2 (NRAMP2) Genes as Examples
- Synergism between Urinary Prothrombin Fragment 1 and Urine: A Comparison of Inhibitory Activities in Stone-Prone and Stone-Free Population Groups
- Immunoglobulin G and Subclass Responses to Plasmodium falciparum Antigens: A Study in Highly Exposed Cameroonians
- Infrequent Somatic Deletion of the 5' Region of the COL1A2 Gene in Oesophageal Squamous Cell Cancer Patients
- The Quantitative Analysis of Zearalenone and Its Derivatives in Plasma of Patients with Breast and Cervical Cancer
- Genetic Polymorphism of Cytochrome P450 1A1 (CYP1A1) and Glutathione Transferases (M1, T1 and P1) among Africans
- Meetings and Awards
