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Reference Intervals for the Markers of Proteinuria with a Standardised Bed-Rest Collection of Urine
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Timo Kouri
Published/Copyright:
June 1, 2005
Abstract
Reference intervals for markers of proteinuria or glomerular charge selectivity were measured in 61 healthy female and 61 healthy male individuals. Timed bed-rest and daytime collections were used to assess significance of preanalytical variability of results. Bed-rest collections are advisable for research on renal damage, whereas in routine care, robust protein/creatinine ratios work as practical estimates of protein excretion rates, the correlations to excretion rates improving with increasing proteinuria. For glomerular charge selectivity, pancreatic/salivary isoamylase clearance ratio showed lower within-subject biological variation than IgG/IgG4 clearance ratio, allowing more accurate classification into normal and reduced charge selectivity. With our method, the lower 2.5% reference intervals for isoamylase clearance ratio were 1.1 in men and 1.9 in women.
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Published Online: 2005-06-01
Published in Print: 2001-06-06
Copyright (c) 2001 by Walter de Gruyter GmbH & Co. KG
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- CCLM: The Near Future
- Granulocyte-Colony Stimulating Factor and Macrophage-Colony Stimulating Factor in Patients with Non-Small-Cell Lung Cancer
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