Erythrocyte Superoxide Dismutase and Glutathione Peroxidase Activities, and Malondialdehyde and Reduced Glutathione Levels in Schizophrenic Patients
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Abstract
There is abundant evidence that free radicals are involved in membrane pathology in the central nervous system and that they may play a role in neuropsychiatric disorders, including schizophrenia. In this study, we investigated erythrocyte superoxide dismutase and glutathione peroxidase activities as antioxidant enzymes, malondialdehydes as a sign of lipid peroxidation, and reduced glutathione levels in schizophrenic patients. Activities of superoxide dismutase and levels of malondialdehyde in erythrocytes were greater in all patients (n=48) and in patients with acute (n=16) and chronic schizophrenia (n=32) (p<0.001 for all patients and chronic patient group; p<0.05 for acute patient group). The activities of glutathione peroxidase were lower in patients (p<0.05 for all patients and acute patient group; p=0.051 for chronic patient group) compared with the control group. Mean erythrocyte reduced glutathione was lower in patients than in controls (p<0.05). In the patient group, erythrocyte superoxide dismutase activity was positively correlated with scales and duration of disease and erythrocyte malondialdehyde concentration. These data reveal that antioxidative defense mechanisms might be impaired in schizophrenic patients.
Copyright © 2000 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Subject Index
- Author Index
- Contents
- Limitations of Randomized Clinical Trials. Proposed Alternative Designs
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- Relationship between Plasma Ammonia Concentration and β-N-Acetylhexosaminidase Isoenzyme Activities in Liver Cirrhosis
- Thiol Redox Status Influences Extracellular Concentration of Homocysteine in HeLa Cell Cultures
- Serum Total and Lipid-Bound Sialic Acid Levels Following Acute Myocardial Infarction
- Concentration of Leukocyte Elastase in Plasma and Polymorphonuclear Neutrophil Extracts in Type 2 Diabetes
- Hypertriglyceridemia Characterized by Low-Density Lipoprotein Phenotype and Lipoprotein Lipase Gene Mutation
- Different Stability of Free and Complexed Prostate-Specific Antigen in Serum in Relation to Specimen Handling and Storage Conditions
- Erythrocyte Superoxide Dismutase and Glutathione Peroxidase Activities, and Malondialdehyde and Reduced Glutathione Levels in Schizophrenic Patients
- Reference Change Value for HbA1c in Patients with Type 2 Diabetes Mellitus
- Specific Oxidase Activity of Cord Serum Ceruloplasmin in the Newborn
- Sequential Evaluation of Serum Urate Concentrations in AIDS Patients with Infections of the Central Nervous System
- Evaluation of Iron Status in Anemic Patients with Rheumatoid Arthritis Using an Automated Immunoturbidimetric Assay for Transferrin Receptor
- IFCC Recommended Reference Method for the Determination of the Substance Concentration of Ionized Calcium in Undiluted Serum, Plasma or Whole Blood
- Current Situation of Clinical Chemistry in Mainland China
- Point of Care Testing. Editors: Christopher P. Price / Jocelyn M. Hicks
- Erratum: Familial Studies on the Genetics of Cardiovascular Diseases: the Stanislas Cohort
- Acknowledgement
Articles in the same Issue
- Subject Index
- Author Index
- Contents
- Limitations of Randomized Clinical Trials. Proposed Alternative Designs
- Haemochromatosis: Automated Detection of the Two Point Mutations in the HFE Gene: Cys282Tyr and His63Asp
- Presence of Group IIa Secretory Phospholipase A2 in Mast Cells and Macrophages in Normal Human Ileal Submucosa and in Crohn's Disease
- Relationship between Plasma Ammonia Concentration and β-N-Acetylhexosaminidase Isoenzyme Activities in Liver Cirrhosis
- Thiol Redox Status Influences Extracellular Concentration of Homocysteine in HeLa Cell Cultures
- Serum Total and Lipid-Bound Sialic Acid Levels Following Acute Myocardial Infarction
- Concentration of Leukocyte Elastase in Plasma and Polymorphonuclear Neutrophil Extracts in Type 2 Diabetes
- Hypertriglyceridemia Characterized by Low-Density Lipoprotein Phenotype and Lipoprotein Lipase Gene Mutation
- Different Stability of Free and Complexed Prostate-Specific Antigen in Serum in Relation to Specimen Handling and Storage Conditions
- Erythrocyte Superoxide Dismutase and Glutathione Peroxidase Activities, and Malondialdehyde and Reduced Glutathione Levels in Schizophrenic Patients
- Reference Change Value for HbA1c in Patients with Type 2 Diabetes Mellitus
- Specific Oxidase Activity of Cord Serum Ceruloplasmin in the Newborn
- Sequential Evaluation of Serum Urate Concentrations in AIDS Patients with Infections of the Central Nervous System
- Evaluation of Iron Status in Anemic Patients with Rheumatoid Arthritis Using an Automated Immunoturbidimetric Assay for Transferrin Receptor
- IFCC Recommended Reference Method for the Determination of the Substance Concentration of Ionized Calcium in Undiluted Serum, Plasma or Whole Blood
- Current Situation of Clinical Chemistry in Mainland China
- Point of Care Testing. Editors: Christopher P. Price / Jocelyn M. Hicks
- Erratum: Familial Studies on the Genetics of Cardiovascular Diseases: the Stanislas Cohort
- Acknowledgement
