Autoantibodies against Oxidized LDL in the First Phase of Life
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Alexandra Steinerová
Abstract
The study presents a comparison of data concerning lipid metabolism and lipid oxidation (oxidative stress) in children at the time of their birth and 3 months later, as well as of their mothers at the time of delivery, compared to a control group of non-pregnant women of the same age. The data confirm that labour represents an oxidative stress for both mother and child; it is expressed as a significant increase of malondialdehyde concentration in mothers immediately after delivery in comparison with non-pregnant women (p < 0.001). Its concentration in newborns was even higher than in their mothers (p < 0.005). Concentration of antibodies against oxidized LDL (oxLDLAb) was comparable in mothers and newborns due to their transplacental transport. During the first three months of life these autoantibodies increased almost two-fold. The importance of this unique observation is discussed with respect to possible early atherogenesis.
Copyright © 1999 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Artificial Neural Networks in Laboratory Medicine and Medical Outcome Prediction
- Mitochondrial Disorders. A Diagnostic Challenge in Clinical Chemistry
- Enrichment of Mutant Alleles by Chromatographic Removal of Wild Type Alleles: a New Principle for the Detection of Alleles with Unknown Point Mutations at Excess of Wild Type Alleles
- Quantitative Differences between Aberrant Transcripts Which Occur as Common Isoforms and due to Mutation-based Exon Skipping of the Mismatch Repair Gene hMLH1
- Analytical and Clinical Performance of Two Cardiac Troponin I Immunoassays
- Development of an Automated Immunoturbidimetric Ferritin Assay
- Does the Uncertainty of Commonly Performed Glucose Measurements Allow Identification of Individuals at High Risk for Diabetes?
- Autoantibodies against Oxidized LDL in the First Phase of Life
- Recommendations of the German Working Group on Medical Laboratory Testing (AML) on the Introduction and Quality Assurance of Procedures for Point-of-Care Testing (POCT) in Hospitals
- Assays for Serum Amyloid A (SAA)
- Practical Introduction to GC/MS Analysis with Quadrupoles, by Michael Oehme
- The Hitchhikers Guide to Effective Time Management, by Christopher S. Frings
