Does the Uncertainty of Commonly Performed Glucose Measurements Allow Identification of Individuals at High Risk for Diabetes?
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Anders Kallner
Abstract
Revised recommendations for diagnosis of diabetes introduce the intermediary risk group of impaired fasting glucose (IFG), defined as individuals with a fasting blood-glucose concentration between 5.6 and 6.0 mmol/l. We apply the concept of uncertainty to identifiable steps of sampling and measuring blood-glucose. Since many instruments in primary health care measure plasma-glucose and report results as blood-glucose and vice versa, factors affecting the transformation are also considered. The study identifies the measurement procedure as the major source of uncertainty, closely followed by preanalytical sources. The estimated uncertainties indicate that the presently available procedures do not allow identification of IFG by a single investigation. The approach to establish an uncertainty budget can be used to evaluate the clinical usefulness of measurements.
Copyright © 1999 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Artificial Neural Networks in Laboratory Medicine and Medical Outcome Prediction
- Mitochondrial Disorders. A Diagnostic Challenge in Clinical Chemistry
- Enrichment of Mutant Alleles by Chromatographic Removal of Wild Type Alleles: a New Principle for the Detection of Alleles with Unknown Point Mutations at Excess of Wild Type Alleles
- Quantitative Differences between Aberrant Transcripts Which Occur as Common Isoforms and due to Mutation-based Exon Skipping of the Mismatch Repair Gene hMLH1
- Analytical and Clinical Performance of Two Cardiac Troponin I Immunoassays
- Development of an Automated Immunoturbidimetric Ferritin Assay
- Does the Uncertainty of Commonly Performed Glucose Measurements Allow Identification of Individuals at High Risk for Diabetes?
- Autoantibodies against Oxidized LDL in the First Phase of Life
- Recommendations of the German Working Group on Medical Laboratory Testing (AML) on the Introduction and Quality Assurance of Procedures for Point-of-Care Testing (POCT) in Hospitals
- Assays for Serum Amyloid A (SAA)
- Practical Introduction to GC/MS Analysis with Quadrupoles, by Michael Oehme
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