Expert Systems for the Interpretation of Serum Proteins
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Robert F. Ritchie
Abstract
The ready availability of inexpensive desk-top computers with enormous disk storage has made the practicality of computer assisted medical interpretive software a reality. There seems little question that these programs could be of enormous help to physicians. However, there are daunting problems to their creation, including the lack of standards for clinical diagnostic precision or accuracy and paucity of helpful literature. As a result, the final products may be quite different. Little effort has been devoted in the laboratory to produce programs which could have great benefit in bridging the gap between laboratorians and clinicians. In a few circumscribed areas where the interpretation of laboratory measurements have been well studied in relation to patient demographics and to the final outcome, the impact has been enormous. The prime example is prenatal diagnosis of neural tube defects, and certain chromosomal and developmental abnormalities. Viewed as an obstacle by most people able and willing to attempt to create such programs is the omnipresence of necessary regulation. A brief overview of the general structure of a program to assist with the interpretation of serum proteins is given as a model in the perspective of current knowledge and state of the relevant literature.
Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Expert Systems for the Interpretation of Serum Proteins
- Proteome in Perspective
- Usefulness of Chromogranin A as a Marker for Detection of Relapses of Carcinoid Tumours
- Comparison of Tissue Polypeptide Antigen (TPA) with Cancer Antigen 15-3 (CA 15-3) and Carcino-embryonic Antigen (CEA) in Follow-up of Breast Cancer
- Continuous Analysis in Extracorporeally Circulating Blood - A Rat Model Applying Flow-Through Ion-Selective Electrodes for the Measurement of Ca2+, K+, Na+ and pH
- Improved Specificity of a New Direct Assay for Urinary Cortisol: Application in Corticoid Treated Patients
- Quantitative Automated Particle-Enhanced Immunonephelometric Assay for the Routinary Measurement of Human Cystatin C
- External Quality Assessment of Stat Test Intralaboratory Turnaround Times. Pilot Study from the Members of the Working Group for the Standardization and Promotion of Turnaround Time Control under the Auspices of the Comitato Italiano per la Standardizzazione die Metodi Ematologici e di Laboratorio
- Biological Effects of Eleven Combined Oral Contraceptives on Serum Triglycerides, γ-Glutamyltransferase, Alkaline Phosphatase, Bilirubin and other Biochemical Variables
- Diagnostic and Prognostic Value of Biochemical Markers in Malignant Bone Disease: A Prospective Study on the Effect of Bisphosphonate on Pain Intensity and Progression of Malignant Bone Disease
- IFCC Committee on Standardization of Markers of Cardiac Damage: Premises and Project Presentation
- Medical Microbiology by C. Mims, J. Playfair, I. Roitt, D. Wakelin and R. Williams
- The Scientist as Consultant. Building New Career Opportunities by Carl J. Sindermann and Thomas K. Sawyer
