Neuron-Specific Enolase: Reference Values in Cord Blood
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Kathrin Kintzel
Abstract
With foetal sonography prenatal detection of tumours has become more frequent. To evaluate and treat these infants it is necessary to identify the tumour postnatally. Elevated neuron-specific enolase is a biochemical marker of neuroblastoma. Since conditions during birth may influence neuron-specific enolase concentration in foetal serum, specific reference values in cord blood are required. Cord blood samples were taken from 192 healthy term newborns and concentration of neuron-specific enolase was measured by enzyme immunoassay (EIA). Median neuron-specific enolase concentration in the reference group was 8.0 μg/l and the 5th–95th percentiles were 4.8–19.4 μg/l. No differences between male and female newborns were detected (p = 0.13).
Measurement of neuron-specific enoloase in cord blood, in comparison with our reference values, offers an early postnatal possibility of confirming the diagnosis of neuroblastoma.
Copyright © 1998 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- The Biochemistry of Gene Therapy for AIDS
- Reticulocytes and Reticulated Platelets: Simultaneous Measurement in Whole Blood by Flow Cytometry
- Salivary Cortisol - an Alternative to Serum Cortisol Determinations in Dynamic Function Tests
- A Time-Resolved Fluorescence Immunoassay for the Measurement of Testosterone in Saliva: Monitoring of Testosterone Replacement Therapy with Testosterone Buciclate
- External Quality Assessment of Molecular Biology-Based Methods Used in Laboratories of Clinical Chemistry and Human Genetics
- Preoperative Values of Molecular Coagulation Markers Identify Patients at Low Risk for Intraoperative Haemostatic Disorders and Excessive Blood Loss
- Rifampicin Causes False-Positive Immunoassay Results for Urine Opiates
- Neuron-Specific Enolase: Reference Values in Cord Blood
- Additional Essential Criteria for Quality Systems of Medical Laboratories
- Low Concentration Monoclonal and Oligoclonal Bands in Serum and Urine Using the Sebia Hydragel Protein Electrophoresis System
