Septins as key regulators of actin based processes in bacterial infection
-
Serge Mostowy
and
Pascale Cossart
Abstract
Many pathogens have evolved a variety of mechanisms to exploit the host-cell actin cytoskeleton during infection, either to enter into cells or to move within cells. These events have been investigated and documented in detail. Yet, a complete picture of the molecules and mechanisms regulating entry and intracellular movement remains to be established. Here we present a series of studies revealing that in addition to actin rearrangements the host cell also employs septins, a relatively newly characterized component of the cell cyto-skeleton, to regulate bacterial entry and restrict the dissemination of cytosolic bacteria. The challenge now is to decipher the precise role of septins during actin rearrangements and how these different cytoskeleton components orchestrate infection processes.
©2011 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Editorial
- Highlight on septins
- HIGHLIGHT: EMBO WORKSHOP ‘SEPTINS’
- New insights into the phylogenetic distribution and evolutionary origins of the septins
- Dynamics of septin ring and collar formation in Saccharomyces cerevisiae
- Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis
- MLL-SEPTIN gene fusions in hematological malignancies
- Septin roles in tumorigenesis
- Characterization of presynaptic septin complexes in mammalian hippocampal neurons
- Characterization of human septin interactions
- Septin genomics: a road less travelled
- Septin9 is involved in septin filament formation and cellular stability
- Lethal phenotype of mice carrying a Sept11 null mutation
- ARTS, the unusual septin: structural and functional aspects
- Structural and biochemical properties of Sept7, a unique septin required for filament formation
- Septins at the annulus of mammalian sperm
- The mother-bud neck as a signaling platform for the coordination between spindle position and cytokinesis in budding yeast
- Evidence that a septin diffusion barrier is dispensable for cytokinesis in budding yeast
- Septins as key regulators of actin based processes in bacterial infection
Articles in the same Issue
- Editorial
- Highlight on septins
- HIGHLIGHT: EMBO WORKSHOP ‘SEPTINS’
- New insights into the phylogenetic distribution and evolutionary origins of the septins
- Dynamics of septin ring and collar formation in Saccharomyces cerevisiae
- Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis
- MLL-SEPTIN gene fusions in hematological malignancies
- Septin roles in tumorigenesis
- Characterization of presynaptic septin complexes in mammalian hippocampal neurons
- Characterization of human septin interactions
- Septin genomics: a road less travelled
- Septin9 is involved in septin filament formation and cellular stability
- Lethal phenotype of mice carrying a Sept11 null mutation
- ARTS, the unusual septin: structural and functional aspects
- Structural and biochemical properties of Sept7, a unique septin required for filament formation
- Septins at the annulus of mammalian sperm
- The mother-bud neck as a signaling platform for the coordination between spindle position and cytokinesis in budding yeast
- Evidence that a septin diffusion barrier is dispensable for cytokinesis in budding yeast
- Septins as key regulators of actin based processes in bacterial infection
