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RNA switches regulate initiation of translation in bacteria
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Stefano Marzi
Published/Copyright:
March 27, 2008
Abstract
A large variety of RNA-based mechanisms have been uncovered in all living organisms to regulate gene expression in response to internal and external changes, and to rapidly adapt cell growth in response to these signals. In bacteria, structural elements in the 5′ leader regions of mRNAs have direct effects on translation initiation of the downstream coding sequences. The docking and unfolding of these mRNAs on the 30S subunit are critical steps in the initiation process directly modulating and timing translation. Structural elements can also undergo conformational changes in response to environmental cues (i.e., temperature sensors) or upon binding of a variety of trans-acting factors, such as metabolites, non-coding RNAs or regulatory proteins. These RNA switches can temporally regulate translation, leading either to repression or to activation of protein synthesis.
Keywords: antisense RNA; initiation; non-coding RNA; regulatory protein; riboswitch; stand-by ribosome; translational control
Published Online: 2008-03-27
Published in Print: 2008-05-01
©2008 by Walter de Gruyter Berlin New York
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Keywords for this article
antisense RNA;
initiation;
non-coding RNA;
regulatory protein;
riboswitch;
stand-by ribosome;
translational control
Articles in the same Issue
- Guest Editorial
- Novel paradigms in vaccine development: from small pox eradication to therapeutic vaccines
- Highlight: 3rd Semmering Conference 2007
- Adaptive immune responses to hepatitis C virus: from viral immunobiology to a vaccine
- Dendritic cell subtypes as primary targets of vaccines: the emerging role and cross-talk of pattern recognition receptors
- Novel strategies to identify biomarkers in tuberculosis
- Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection
- Lipopolysaccharide: a tool and target in enterobacterial vaccine development
- The coming of age of virus-like particle vaccines
- Maintenance of serological memory
- Adjuvant activity of type I interferons
- Japanese encephalitis vaccines – needs, flaws and achievements
- Analysis of the human cytomegalovirus pp65-directed T-cell response in healthy HLA-A2-positive individuals
- Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old age
- Pre-clinical development of cell culture (Vero)-derived H5N1 pandemic vaccines
- Construction of an encapsulated ESAT-6-based anti-TB DNA vaccine and evaluation of its immunogenic properties
- Review
- RNA switches regulate initiation of translation in bacteria
- Protein Structure and Function
- Inhibition of bacterial oxidases by formamide and analogs
- Modeling of variant copies of subunit D1 in the structure of photosystem II from Thermosynechococcus elongatus
