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Bradykinin and peripheral sensitization

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Published/Copyright: January 13, 2006
Biological Chemistry
From the journal Volume 387 Issue 1

Abstract

Pain hypersensitivity after tissue injury and inflammation is contributed to by a reduction in the threshold and an increase in the responsiveness of the peripheral terminals of high-threshold nociceptor neurons, the phenomenon of peripheral sensitization. Bradykinin, acting via G-protein-coupled receptors expressed by the sensory neurons, links to multiple intracellular signaling pathways that in turn interact with voltage-gated and ligand-gated ion channels, changing their properties in such a way as to enhance the response to peripheral stimuli.

Keywords: bradykinin; ion channels; nociceptors; pain hypersensitivity; peripheral sensitization; TRPs
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References

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Published Online: 2006-01-13
Published in Print: 2006-01-01

©2006 by Walter de Gruyter Berlin New York

Articles in the same Issue

  1. Editor's Note
  2. Endothelial mediators and communication through vascular gap junctions
  3. Bradykinin and peripheral sensitization
  4. Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes
  5. Solvent-induced changes in photochemical activity and conformation of photosystem I particles by glycerol
  6. Interaction of the BELL-like protein ATH1 with DNA: role of homeodomain residue 54 in specifying the different binding properties of BELL and KNOX proteins
  7. Vitamin B1de novo synthesis in the human malaria parasite Plasmodium falciparum depends on external provision of 4-amino-5-hydroxymethyl-2-methylpyrimidine
  8. Ecto- and cytosolic 5′-nucleotidases in normal and AMP deaminase-deficient human skeletal muscle
  9. Dual signal transduction mediated by a single type of olfactory receptor expressed in a heterologous system
  10. Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells
  11. The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NF-κB activation
  12. Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage
  13. Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion
  14. A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration
  15. NF-κB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells
https://doi.org/10.1515/BC.2006.003
Keywords for this article
bradykinin; ion channels; nociceptors; pain hypersensitivity; peripheral sensitization; TRPs

Articles in the same Issue

  1. Editor's Note
  2. Endothelial mediators and communication through vascular gap junctions
  3. Bradykinin and peripheral sensitization
  4. Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes
  5. Solvent-induced changes in photochemical activity and conformation of photosystem I particles by glycerol
  6. Interaction of the BELL-like protein ATH1 with DNA: role of homeodomain residue 54 in specifying the different binding properties of BELL and KNOX proteins
  7. Vitamin B1de novo synthesis in the human malaria parasite Plasmodium falciparum depends on external provision of 4-amino-5-hydroxymethyl-2-methylpyrimidine
  8. Ecto- and cytosolic 5′-nucleotidases in normal and AMP deaminase-deficient human skeletal muscle
  9. Dual signal transduction mediated by a single type of olfactory receptor expressed in a heterologous system
  10. Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells
  11. The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NF-κB activation
  12. Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage
  13. Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion
  14. A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration
  15. NF-κB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells
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