Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer
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Konstantina Mathioudaki
, Andreas Scorilas , Alexandra Papadokostopoulou , Dimitrios Xynopoulos , Niki Arnogianaki , Niki Agnanti and Maroulio Talieri
Abstract
Apoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported. Expression analysis of the BCL2L12 gene in breast cancer confirmed an association of BCL2L12 with favorable prognosis of patients. In the present study, the expression of the BCL2L12 gene was analyzed in colon cancer by RT-PCR. Two transcripts, BCL2L12 and BCL2L12-A, were overexpressed in the cancer tissues as compared to their paired normal mucosa. An association was found between BCL2L12-A transcript expression and nodal status, as well as Dukes’ stage. The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression.
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Articles in the same Issue
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- Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer
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Articles in the same Issue
- Tapasin and other chaperones: models of the MHC class I loading complex
- Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer
- SR-A1, a member of the human pre-mRNA splicing factor family, and its expression in colon cancer progression
- RNA interference by small hairpin RNAs synthesised under control of the human 7S K RNA promoter
- Kinetic characterization of phenol and aniline derivates as substrates of peroxidase
- Non-muscle α-actinin-4 interacts with plasminogen activator inhibitor type-1 (PAI-1)
- Oxidative modification of low-density lipoprotein: lipid peroxidation by myeloperoxidase in the presence of nitrite
- An apoptotic inducer, aralin, is a novel type II ribosome-inactivating protein from Aralia elata
- Inhibition of inducible TNF-α expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale
- Inhibition of sequestration of human B2 bradykinin receptor by phenylarsine oxide or sucrose allows determination of a receptor affinity shift and ligand dissociation in intact cells
- Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice
- Comprehensive analysis of metabolites in Corynebacterium glutamicum by gas chromatography/mass spectrometry