Role of reporter gene imaging in molecular and cellular biology
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P. Mayer-Kuckuk
Abstract
Molecular imaging, including reporter gene methods, provides a unique opportunity to study biology in a living subject, thereby allowing physiological events to be monitored in an intact microenvironment. This review takes a molecular and cell biology perspective on recent studies which utilize reporter gene imaging as a tool to noninvasively monitor specific molecular biology pathways in vivo. Studies in rodent models demonstrate the feasibility of reporter gene imaging to visualize and measure key cellular pathways, such as transcription, translation and protein-protein interactions. The review indicates that molecular imaging is likely to be useful in the translation of molecular biology to medicine and biotechnological applications.
Copyright © 2004 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Publishers Note
- Role of reporter gene imaging in molecular and cellular biology
- Comprehensive search for cysteine cathepsins in the human genome
- Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions
- Identification of arginine residues important for the activity of Escherichia coli signal peptidase I
- Characterization of pancreatic ERj3p, ahomolog of yeast DnaJ-like protein Scj1p
- Carbohydrate moieties can induce mediator release: a detailed characterization of two major timothy grass pollen allergens
- The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity
- Activation of NF-κB/Rel transcription factors in human primary peripheral blood mononuclear cells by interleukin 7
- Cystatin SA, a cysteine proteinase inhibitor, induces interferon-γ expression in CD4-positive T cells
- Inhibition of human pancreatic proteinases by human plasma α2-antiplasmin and antithrombin
- New protease inhibitors from buckwheat seeds: properties, partial amino acid sequences and possible biological role
- Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate
- Cathepsins K, L, B, X and W are differentially expressed in normal and chronically inflamed gastric mucosa
