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Modulation of the Activation of Extracellular Signal-Regulated Kinase (ERK) and the Production of Inflammatory Mediators by ADP-Ribosylation Inhibitors

  • C. Le Page and J. Wietzerbin
Published/Copyright: June 1, 2005
Biological Chemistry
From the journal Volume 384 Issue 10-11

Abstract

ADP-ribosylation is involved in nuclear factor κB (NF-κB)-dependent gene expression induced by lipopolysaccharide in murine macrophages. Here we have investigated the mechanism by which ADP-ribosylation inhibitors block signaling pathways induced in macrophages. In RAW264.7 macrophages the inducers of NF-κB activate the production of reactive oxygen species and three mitogenactivated protein kinases (MAPK), the extracellular signal regulated kinase (ERK), the c-jun N-terminal kinase/stress-activated protein kinase (JNK), and p38. We demonstrate that ADP-ribosylation inhibitors specifically inhibit ERK MAPK activation and reduce the release of inflammatory mediators such as tumor necrosis factor α (TNF-α), IL-6 and nitrite.

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Published Online: 2005-06-01
Published in Print: 2003-11-07

Copyright © 2003 by Walter de Gruyter GmbH & Co. KG

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  17. Modulation of the Activation of Extracellular Signal-Regulated Kinase (ERK) and the Production of Inflammatory Mediators by ADP-Ribosylation Inhibitors
  18. Increase of Anti-Metastatic Efficacy by Selectivity- But Not Affinity-Optimization of Synthetic Serine Protease Inhibitors
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https://doi.org/10.1515/BC.2003.167

Articles in the same Issue

  1. Mechanisms and Biological Consequences of Nitrosative Stress
  2. Regulation of the Expression of Inducible Nitric Oxide Synthase
  3. Nitrosative Stress and Transcription
  4. Nitric Oxide Signalling with a Special Focus on Lipid-Derived Mediators
  5. Potential of Embryonic and Adult Stem Cells in vitro
  6. Ribosomal Tolerance and Peptide Bond Formation
  7. Transcription of Cathepsin B in Glioma Cells: Regulation by an E-Box Adjacent to the Transcription Initiation Site
  8. The Catalytically Active Domain in the A Subunit of Calcineurin
  9. HIV TAT Basic Peptide Is Not a High-Affinity Ligand for VEGF Receptor 2
  10. Immunogenicity and Protectivity of Plasmodium falciparum EBA-175 Peptide and Its Analog Is Associated with α-Helical Region Shortening and Displacement
  11. Gene Organization and Molecular Modeling of Copper Amine Oxidase from Aspergillus niger: Re-Evaluation of the Cofactor Structure
  12. Thermodynamic Analysis of the Dissociation of the Aldolase Tetramer Substituted at One or Both of the Subunit Interfaces
  13. Molecular Recognition between Azotobacter vinelandii Rhodanese and a Sulfur Acceptor Protein
  14. Cloning and Characterization of a Transmembrane-Type Serine Protease from Rat Kidney, a New Sodium Channel Activator
  15. Aptamers That Recognize the Lipid Moiety of the Antibiotic Moenomycin A
  16. Suboptimal Action of NF-κB in Fanconi Anemia Cells Results from Low Levels of Thioredoxin
  17. Modulation of the Activation of Extracellular Signal-Regulated Kinase (ERK) and the Production of Inflammatory Mediators by ADP-Ribosylation Inhibitors
  18. Increase of Anti-Metastatic Efficacy by Selectivity- But Not Affinity-Optimization of Synthetic Serine Protease Inhibitors
  19. Mast Cell Cathepsins C and S Control Levels of Carboxypeptidase A and the Chymase, Mouse Mast Cell Protease 5
  20. Application of the C4'-Alkylated Deoxyribose Primer System (CAPS) in Allele-Specific Real-Time PCR for Increased Selectivity in Discrimination of Single Nucleotide Sequence Variants
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