Nitric Oxide Signalling with a Special Focus on Lipid-Derived Mediators
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A. Huwiler
Abstract
The ways in which cells communicate among each other concerns all aspects of biology, from developmental processes to diseases. Nitric oxide (NO) is one of the most remarkable and unusual regulatory molecules. It is a labile free radical gas that is not stored but generated on demand, and has been implicated in an extraordinarily diverse range of physiological and pathophysiological functions. The modulation of cell signalling by free radicals is an emerging area of research that provides insight into the orchestration of cell adaptation to a changing microenvironment. In a multicellular organism this serves to coordinate complex physiological responses, such as inflammation. Cell signalling is also accompanied by rapid remodelling of membrane lipids by activated lipases. The discovery that NO, which does not reversibly interact with membrane receptors like conventional hormones and growth factors, targets enzymes such as phospholipase A2, sphingomyelinases or ceramidases, has stimulated growing interest in the crosstalk between redox and lipid signalling.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Mechanisms and Biological Consequences of Nitrosative Stress
- Regulation of the Expression of Inducible Nitric Oxide Synthase
- Nitrosative Stress and Transcription
- Nitric Oxide Signalling with a Special Focus on Lipid-Derived Mediators
- Potential of Embryonic and Adult Stem Cells in vitro
- Ribosomal Tolerance and Peptide Bond Formation
- Transcription of Cathepsin B in Glioma Cells: Regulation by an E-Box Adjacent to the Transcription Initiation Site
- The Catalytically Active Domain in the A Subunit of Calcineurin
- HIV TAT Basic Peptide Is Not a High-Affinity Ligand for VEGF Receptor 2
- Immunogenicity and Protectivity of Plasmodium falciparum EBA-175 Peptide and Its Analog Is Associated with α-Helical Region Shortening and Displacement
- Gene Organization and Molecular Modeling of Copper Amine Oxidase from Aspergillus niger: Re-Evaluation of the Cofactor Structure
- Thermodynamic Analysis of the Dissociation of the Aldolase Tetramer Substituted at One or Both of the Subunit Interfaces
- Molecular Recognition between Azotobacter vinelandii Rhodanese and a Sulfur Acceptor Protein
- Cloning and Characterization of a Transmembrane-Type Serine Protease from Rat Kidney, a New Sodium Channel Activator
- Aptamers That Recognize the Lipid Moiety of the Antibiotic Moenomycin A
- Suboptimal Action of NF-κB in Fanconi Anemia Cells Results from Low Levels of Thioredoxin
- Modulation of the Activation of Extracellular Signal-Regulated Kinase (ERK) and the Production of Inflammatory Mediators by ADP-Ribosylation Inhibitors
- Increase of Anti-Metastatic Efficacy by Selectivity- But Not Affinity-Optimization of Synthetic Serine Protease Inhibitors
- Mast Cell Cathepsins C and S Control Levels of Carboxypeptidase A and the Chymase, Mouse Mast Cell Protease 5
- Application of the C4'-Alkylated Deoxyribose Primer System (CAPS) in Allele-Specific Real-Time PCR for Increased Selectivity in Discrimination of Single Nucleotide Sequence Variants
Articles in the same Issue
- Mechanisms and Biological Consequences of Nitrosative Stress
- Regulation of the Expression of Inducible Nitric Oxide Synthase
- Nitrosative Stress and Transcription
- Nitric Oxide Signalling with a Special Focus on Lipid-Derived Mediators
- Potential of Embryonic and Adult Stem Cells in vitro
- Ribosomal Tolerance and Peptide Bond Formation
- Transcription of Cathepsin B in Glioma Cells: Regulation by an E-Box Adjacent to the Transcription Initiation Site
- The Catalytically Active Domain in the A Subunit of Calcineurin
- HIV TAT Basic Peptide Is Not a High-Affinity Ligand for VEGF Receptor 2
- Immunogenicity and Protectivity of Plasmodium falciparum EBA-175 Peptide and Its Analog Is Associated with α-Helical Region Shortening and Displacement
- Gene Organization and Molecular Modeling of Copper Amine Oxidase from Aspergillus niger: Re-Evaluation of the Cofactor Structure
- Thermodynamic Analysis of the Dissociation of the Aldolase Tetramer Substituted at One or Both of the Subunit Interfaces
- Molecular Recognition between Azotobacter vinelandii Rhodanese and a Sulfur Acceptor Protein
- Cloning and Characterization of a Transmembrane-Type Serine Protease from Rat Kidney, a New Sodium Channel Activator
- Aptamers That Recognize the Lipid Moiety of the Antibiotic Moenomycin A
- Suboptimal Action of NF-κB in Fanconi Anemia Cells Results from Low Levels of Thioredoxin
- Modulation of the Activation of Extracellular Signal-Regulated Kinase (ERK) and the Production of Inflammatory Mediators by ADP-Ribosylation Inhibitors
- Increase of Anti-Metastatic Efficacy by Selectivity- But Not Affinity-Optimization of Synthetic Serine Protease Inhibitors
- Mast Cell Cathepsins C and S Control Levels of Carboxypeptidase A and the Chymase, Mouse Mast Cell Protease 5
- Application of the C4'-Alkylated Deoxyribose Primer System (CAPS) in Allele-Specific Real-Time PCR for Increased Selectivity in Discrimination of Single Nucleotide Sequence Variants
