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Mitochondrial Single-Stranded DNA-Binding Proteins: in Search for New Functions
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L'ubomír Tomáka
Published/Copyright:
June 1, 2005
Abstract
During the evolution of the eukaryotic cell, genes encoding proteins involved in the metabolism of mitochondrial DNA (mtDNA) have been transferred from the endosymbiont into the host genome. Mitochondrial singlestranded DNAbinding (mtSSB) proteins serve as an excellent argument supporting this aspect of the endosymbiotic theory. The crystal structure of the human mtSSB, together with an abundance of biochemical and genetic data, revealed several exciting features of mtSSB proteins and enabled a detailed comparison with their prokaryotic counterparts. Moreover, identification of a novel member of the mtSSB family, mitochondrial telomerebinding protein of the yeast Candida parapsilosis, has raised interesting questions regarding mtDNA metabolism and evolution.
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Published Online: 2005-06-01
Published in Print: 2001-02-12
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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