BINDING PROTEINS IN PLASMA AND LIVER CYTOSOL, AND TRANSPORT OF BILIRUBIN

Chapters in this book

1. Frontmatter I
2. PREFACE V
3. CONTENTS IX
4. LIST OF CONTRIBUTORS XIII
5. SECTION I . GENERAL
6. THERMODYNAMICS OF PROTEIN- LIGAND INTERACTIONS 3
7. CLASSIFICATION OF TRANSPORT MECHANISMS BY NON-EQUILIBRIUM THERMODYNAMICS 15
8. CHEMICAL RELAXATION SPECTROMETRY: INVESTIGATION OF MECHANISMS INVOLVED IN MEMBRANE PROCESSES 27
9. ¹³c NMR STUDIES OF GLYCOLYSIS IN SUSPENSIONS OF ESCHERICHIA COLI CELLS 47
10. SECTION II . SELECTED TRANSPORT PROTEINS
11. SERUM ALBUMIN AS A TRANSPORT PROTEIN 57
12. LIGANDIN AND PROTEIN A: INTRACELLULAR BINDING PROTEINS 79
13. THE ABSENCE OF HEME-HEME INTERACTION AT THE IRON ATOMS OF HEMOGLOBIN 95
14. MULTI ENZYME COMPLEXES. MOLECULAR ORGANIZATION AND FUNCTIONAL INTERACTION OF ACTIVE SITES WITHIN THE FATTY ACID SYNTHETASE MULTIENZYME COMPLEX OF YEAST 103
15. MODES OF REDOX-TRANSPORT BY PROTEINS: "HYDRIDE" AND "CARBANION" VERSUS ELECTRON TRANSPORT 123
16. THE MECHANISM OF ENERGY TRANSDUCTION IN PHOTOPHOSPHORYLATION 151
17. SECTION III. MEMBRANES AND TRANSPORT BY PROTEINS
18. PROTEINS IN MITOCHONDRIAL CALCIUM TRANSPORT 171
19. CONFORMATIONAL CHANGES AND COOPERATIVITY IN THE MECHANISM OF PROTON TRANSFER IN BACTERIORHODOPSIN 187
20. PROTEINS OF BACTERIAL ACTIVE TRANSPORT SYSTEMS 199
21. THE DEPENDENCE OF MEDIATED TRANSPORT SYSTEMS ON THE CHOLESTEROL CONTENT OF THE MEMBRANE 215
22. ION CHANNELS IN EXCITABLE MEMBRANES 221
23. SECTION IV. METAL TRANSPORT BY PROTEINS
24. FERRITIN IROW DEPOSITION AMD MOBILISATION : MOLECULAR MECHANISMS AND CELLULAR CONSEQUENCES 243
25. THE FERRITIN MOLECULE: A SIMK AND A SOURCE FOR IRON 259
26. THERMODYNAMIC AND ACCESSIBILITY FACTORS IN THE SPECIFIC BINDING OF IRON TO HUMAN TRANSFERRIN 277
27. HEME TRANSPORT AND PROPERTIES OF HEMOPEXIN 295
28. A GENETIC DEFECT IN THE TRANSPORT OF CERULOPLASMIN-COPPER FROM BLOOD TO B I L E AS THE POSSIBLE PATHOGENESIS OF W I L S O N ' S DISEASE 311
29. SECTION V. MOLECULAR ASPECTS OF TRANSPORT BY PROTEINS IN PHYSIOLOGY AND PHARMACOLOGY
30. PHARMACOLOGICAL CONSEQUENCES OF PLASMA PROTEIN AND TISSUE BINDING OF DRUGS 325
31. THE EFFECTS OF TRYPTOPHAN AND TYROSINE MODIFICATION ON THE DRUG-BINDING PROPERTIES OF HUMAN SERUM ALBUMIN 341
32. TRANSFER OF FERRIPROTOPORPHYRIN IX FROM HUMAN SERUM ALBUMIN TO APOMYOGLOBIN IN AQUEOUS SOLUTION 355
33. THE ROLE OF INTRACELLULAR PROTEINS IN THE TRANSPORT AND METABOLISM OF LIPOPHILIC COMPOUNDS 369
34. BINDING PROTEINS IN PLASMA AND LIVER CYTOSOL, AND TRANSPORT OF BILIRUBIN 387
35. CONCLUDING REMARKS 405
36. INDEX OF CONTRIBUTORS 409
37. SUBJECT INDEX 411