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book: Insulin, chemistry, structure, and function of insulin and related hormones
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Insulin, chemistry, structure, and function of insulin and related hormones

Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979
  • Edited by: and
Language: English
Published/Copyright: 1980
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    Frontmatter

    I
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    ACKNOWLEDGEMENTS

    VIII
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    Preface

    IX
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    CONTENTS

    XI
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    INTRODUCTION

    1
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  • SECTION I. STRUCTURE OF INSULIN
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    A Comparison Between the Insulin Molecules in 2-Zinc and 4-Zinc Insulin Crystals

    9
    E.J. Dodson, G.G. Dodson, Reynolds and D. Vallely
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    Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid

    17
    G.G. Dodson, S. Cutfield, E. Hoenjet, A. Wollmer and D. Brandenburg
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    Correlation of Structural Details of Insulin in the Crystal and in Solution

    27
    A. Vollmer, W. Straßburger, E. Hoenjet, U. Glatter, J. Fleischhauer, D.A. Mercola, R.A.G. de Graaf, E.J. Dodson, G.G. Dodson, D.G. Smith, D. Brandenburg and W. Danho
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  • SECTION II. PEPTIDE SYNTHESIS
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    An Assessment of Protecting Group Strategies in Synthesis of Large Peptides

    39
    J. Meienhofer
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    Fully Active Semisynthetic Insulin by Selective Formation of the Disulfide Bridges as an Intermediate Result of the Total Synthesis by Fragment Condensation on Polymer Phase

    51
    C. Birr, R. Pipkorn, H.-G. Gattner, R. Renner and H.-U. Häring
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    [A14-Phenylalanine-Insulin]: A Synthetic Analogue

    59
    W. Danho, A. Sasaki, E. Büllesbach, H.-G. Gattner and A. Wollmer
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    [B25-Tyrosine]B-Chain-S-Sulfonate of Porcine Insulin

    67
    R. Knorr, W. Danho, E. Büllesbach, H.-G. Gattner and E. Zahn
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    The Synthesis of [B25-4-Nitrophenylalanine]-Octapeptide B(23-30) of Porcine Insulin

    73
    M. Casaretto, W. Danho, Gattner and H. Zahn
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    A Novel Route for the Preparation of Mono-Iodotyrosine and Mono-Iodotyrosine-Containing Peptides by Electrochemical Reduction of Di-Iodo Derivatives

    77
    H.-G. Gattner and W. Danho
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    Alternative Approach for Human Proinsulin Synthesis

    81
    N. Yanaihara, M. Sakagami and C. Yanaihara
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    An Alternative Synthesis of Glucagon by the Method of Solid Phase Condensation of Peptide Fragments

    91
    Y-T. Kung, D-Y. Zhu, X-D. Qiu, X-W. Yuan, L-T. Ke and W. Wei
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  • SECTION III. SEMISYNTHESIS AND CHEMICAL MODIFICATION
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    Progress Towards the Semisynthesis of Preproinsulin

    99
    V.K. Naithani, E.E. Büllesbach, H. Zahn, J. Shield, R. Chance and M.A. Root
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    Specific Activation of the Arginine Carboxyl Group of the B-Chain of Bovine Des-Octapeptide-(B23-30)-Insulin

    107
    E. Canova-Davis and F.H. Carpenter
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    Enzyme-Catalyzed Semisynthesis with Insulin Derivatives

    117
    H.-G. Gattner, W. Danho and V.K. Naithani
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    The Relative Reactivity of Insulin Amino Groups as an Indicator of Structural Accessibility and its Use for Synthetic Approaches for Structure-Function Studies

    125
    H.-J. Friesen
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    A14-(N-Methylpyridinium) and A14-(2-Nitro-4-Trimethylammoniophenyl) Derivatives of Bovine Insulin

    135
    S.E. Drewes, B.R.D. Easter, H.M. Robinson and H.E.M. Magojo
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    Preparation of Covalent Insulin Dimers

    143
    A. Schüttler and D. Brandenburg
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    Reactions of Insulin Derivatives with ETAC Reagents

    151
    R.G. Lawton
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  • SECTION IV. RADIOACTIVE LABELLING AND SEPARATION TECHNIQUES
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    The Application of HPLC to the Analysis of Radio- Iodinated Tracers of Glucagon and Insulin

    161
    J. Markussen and U.D. Larsen
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    Monoiodoinsulin Specifically Substituted in A14-Tyr or A19-Tyr

    169
    B. Hansen, S. Linde, 0. Sonne and J. Gliemann
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    Preparation of Homogeneous Insulin Tracers with Monoand Di-Iodo-Desaminotyrosines in Position B1

    177
    S. Bahrami and D. Brandenburg
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    Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium

    185
    H. Tschesche, W. Behr and R. Wick
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    Radioactive Labelling (14 C, 3 H) of Insulin and Insulin Derivatives by Reductive Methylation; Isolation of Homogeneous N, N-Di-Methylated Derivatives

    191
    J. Uschkoreit, D. Brandenburg and H.-J. Friesen
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    Quantitative Determination of Insulin by Gradient Elution HPLC

    201
    M.E.F. Biemond, W.A. Sipman and J Olivié
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    Some Preliminary Findings in Isotachophoretic Analyses of Insulin

    207
    A. Baldesten
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    Studies on the Denaturation of Dissolved Insulin

    215
    H. Thurow
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  • SECTION V. RECEPTORS AND HORMONE-RECEPTOR INTERACTION
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    125 I-SpHPP-Avidin: A Tool for Hormone Receptor Studies

    225
    F.M. Finn and K. Hofmann
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    Chromatographic Properties of the Adipocyte Transport System in Detergent Solution and its Resolution from the Insulin Receptor

    233
    M.P. Czech, C. Carter-Su and P.F. Pilch
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    Hydrophobic Interaction Chromatography as a Tool in Insulin Receptor Purification

    243
    L. Kuehn, H. Meyer and H. Reinauer
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    Localization of Insulin-Receptor Complexes on the Surface of Whole Cells by Autoradiography

    251
    E. Junger, C. Giesen, M. Semmler, H. Reinauer and L. Bachmann
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    Insulin Receptors in the Heart Muscle: Evidence for the Negative Cooperativity Binding Model

    259
    J. Eckel and H. Reinauer
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    Insulin Receptors, Insulin Degradation, and Biological Activity

    263
    O. Sonne and J. Gliemann
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    Regulation of Insulin Receptors in Isolated Hepatocytes from Normal and Streptozotocin-Diabetic Rats in the Fed and 48 H Fasted State

    271
    S. Gammeltoft, L.Ø.. Kristensen, M. Folke and L. Sestoft
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    Insulin-Receptor Turnover and Down Regulation

    277
    S. Terris and D.F. Steiner
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    Receptor-Mediated Internalisation of Insulin, Glucagon and Growth Hormone in Intact Rat Liver. A Biochemical Study

    285
    B. Desbuquois and M.-C. Postel-Vinay
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    Kinetics of Insulin Binding to Its Receptors in vivo. Effects of Fasting

    293
    J.C. Sodoyez, F. Sodoyez-Goffaux and Y.M. Thiry-Moris
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    Hystricomorph Insulins and Insulin Receptors

    301
    N.R. Lazarus, K. O’Connor, R.W.J. Neville, P. Goodwin, R. Horuk and D. Stone
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  • SECTION VI. PHOTO-INDUCED HORMONE-RECEPTOR COUPLING
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    Photoreactive Insulin Derivatives: Preparation and Characterization

    309
    P. Thamm, D. Saunders and D. Brandenburg
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    Photoreactive Insulin Derivatives: Chemical and Physical Properties

    317
    D. Saunders, P. Thamm and D. Brandenburg
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    The Preparation and Application of an A1-Substituted Photo-Reactive Insulin Analogue

    327
    A.R. Rees and M.R. Whittle
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    Photoaffinity Labeling of Insulin Receptor Proteins of Liver Plasma Membranes

    337
    C.C. Yip, C.W.-T. Yeung and M.L. Moule
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    Characterisation of Insulin Binding Sites in Rat Liver Plasma Membranes Using Photoreactive Insulin Analogues

    345
    M.H. Wisher, P. Thamm, D. Saunders, P.H. Sönksen and D. Brandenburg
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    Permanent Activation of Lipogenesis by Insulin Covalently Bound to Adipocyte Receptors

    353
    C. Diaconescu, P. Thamm, D.J. Saunders and D. Brandenburg
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  • SECTION VII. STRUCTURE, BINDING, ACTIVITY
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    The Activation of Adenylate Cyclase by Chemically Modified Forms of Glucagon and its Relationship to Receptor Binding

    363
    R.M. Epand
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    Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites

    371
    M. Piron, M. Michiels-Place, M. Waelbroeok, P. De Meyts, A. Schüttler and D. Brandenburg
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    Properties of a Mutant Insulin Species Causing Human Diabetes

    393
    J.M. Olefsky, M. Saekow, M. Kobayashi, O.G. Kolterman, H. Tager, B. Given, D. Baldwin, M. Mako, J. Markese, A.M. Hubenstein and H. Poucher
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    A1-Modified Insulins: Receptor Binding and Biological Activity

    403
    P. Rösen, M. Simon, H. Reinauer, D. Brandenburg, H. -J. Friesen and C. Diaconescu
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    Biological Activity of Insulin Analogues Substituted at the Amino Group of B1-Phenylalanine

    409
    R. Geiger, R. Obermeier, V. Teetz, R. Uhmann, H.D. Summ, H. Neubauer, K. Geisen and G. Regitz
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    Functional Role of the N-Terminal Region of the B-Chain of Insulin

    417
    C. W.-T. Yeung, M.L. Moule and C.C. Sip
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    Biological Properties of Covalent Insulin Dimers

    425
    K.P. Willey, M.A. Tatnell, R.H. Jones, A. Schüttler and D. Brandenburg
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    Biological Activity and Receptor Binding of Six Different Covalent Dimers of Insulin

    433
    K. Schlüter, K.-G. Petersen, A. Schüttler, D. Brandenburg and L . Kerp
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    In vitro and in vivo Effects of Poly-N-Vinylpyrrolidone- Insulin

    439
    H.J. Kolb, R. Renner, B.U. von Specht and K.D. Hepp
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    Study of Insulin Action by Use of Insulin-Dextran Complex: Uptake of Insulin into Subcellular Fractions and Stimulation of Pyruvate Dehydrogenase in Mouse Adipocytes

    447
    Y. Sakamoto and T. Kuzuya
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    Studies on the Mechanism of Insulin Action VI: The Interaction of Insulin Fragments with Insulin Receptor

    455
    Y-M Feng, J-L. Gu, X-T. Zhang, Z-X. Lu, W-J. Xu and J-H Zhu
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    Stimulation of Intracellular H2 02 Production in Rat Epididymal Adipocytes by Insulin, Insulin Fragments, and Other Hormones and Growth Factors with Insulin-Like Activities

    461
    C. de Haën, D.B. Muchmore and S.A. Little
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    Early Events in Insulin Binding and Insulin Action in Fat Cells and Hepatocytes

    469
    H. Häring, D.G. Brocks, E.A. Siess and W. Kemmler
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    Role of the Biodegradation Process in the Action of Insulin. A Proposal for a Model Consisting of Sulfhydryl- Disulfide Interchange Reaction and Proteolysis

    475
    P.T. Varandani
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    Insulin Receptors, Receptor Antibodies and the Mechanism of Insulin Action

    483
    C.R. Kahn, C. Grunfeld, G.L. King, E. Van Obberghen and K.L. Baird
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  • SECTION VIII. DEGRADATION
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    Studies on Uptake of [3 H]-Insulin by Erythrocytes

    495
    W. Behr and H. Tsohesahe
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    An Insulin-Degrading Enzyme from Human Erythrocytes: Isolation and Characterization

    501
    H.J. Kolb and E. Standl
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    Comparison of 125 I-Insulin and [B1- 3 H-Phenylalanine]- Insulin Degradation by Insulin Protease

    509
    W.C. Duckworth and P.A. Halban
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    The Chemical Characterization of the Products of the Processing of Subcutaneously Injected Insulin

    517
    J.G. Davies, R.E. Offord, P.A. Halban and M. Berger
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    Some Inhibitors of Insulin Degradation

    525
    R.E. Offord, J. Philippe, S.M. Hoare, P.A. Halban and M. Berger
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    Excretion of Endogenous and Exogenous Insulin by Kidney in Diabetic Ketoacidosis

    531
    H.S. Sacks, F.B. Stenz and A.E. Kitabohi
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    Incubation of Insulin in Hyperglycemic Blood Generates Insulin Dimers

    539
    T.R. Csorba, M.M. Cannon, M. Ungar and N.S. Track
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  • SECTION IX. IMMUNOLOGY
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    Genetic Regulation of the Immune Response of Mice to Insulins of Different Species

    551
    K. Keck and M. Momayezi
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    Genetic Control of the Immune Response to Insulin

    559
    A.S. Rosenthal, J.W. Thomas, J. Schroer, W. Danho, E. Büllesbach and J. Föhles
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    Analysis of the Immunogenicity of Three Insulin- Preparations

    569
    U. Kiesel, F.K. Jansen, D. Brandenburg and H.-G. Gattner
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    Studies on the Immunological Properties of Natural and Modified Insulins

    575
    H.P. Neubauer and H.H. Schöne
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    Genetic Control of the Immune Response to Insulin: A Clinical Study of Adverse Immunologic Reactions to Insulin

    585
    A.S. Rosenthal, J.T. Blake, C.R. Kahn, D. Mann and J. Galloway
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    The Induction of Hyperglycemia with Insulin Antibodies to B-Chain Determinants

    593
    E.R. Arquilla, J.M. Kelso, I.Y. Tamai and M.D. Roth
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    The Pattern of B-Lymphocyte Specificities for Modified and Unmodified Insulins in the Mouse

    603
    U. Kiesel and H-G. Gattner
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    Specificity of Rabbit Anti-Insulin Antibody

    611
    K. Keck, K. Jäger, R. Geiger, D. Brandenburg and H.-G. Gattner
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    Radioimmunoassay of Chemically-Modified Insulins - Use and Misuse

    619
    J.H. Thomas, D.I. Dron, R.H. Jones, P.H. Sönksen and D. Brandenburg
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    Purity of Chromatographycally Purified Insulins Measured by Skin-Reactivity and Insulin-Specific IGE

    627
    H.-G. Velcovsky, E. Mäser and K. Federlin
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  • SECTION X. BIOSYNTHESIS, STORAGE, EVOLUTION
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    Human Preproinsulin: Primary Structure of the Messenger RNA

    637
    A. Ullrich, D.V. Goeddel, A. Gray and I. Sures
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    Quantification of Proinsulin Biosynthesis by Determination of Specific Radioactivity of [3 H]-Leucine in Pancreatic Islets

    643
    S. Schmidt, D. Schröder, H. Jahr and H. Zühlke
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    Immunoreactive Rat C-Peptides I and II in Glucose Perfusate of Isolated Pancreas

    651
    C. Yanaihara, J. Ozaki, N. Nishida, N. Yanaihara and T. Keneko
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    Biosynthesis of Somatostatin in Pancreatic Islets of Wistar Rats

    659
    S. Schmidt, H. Zühlke, D. Schröder, M. Ziegler and H. Jahr
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    Crystallography of Intracellular Insulin and Glucagon as Revealed by Investigations of Tissues and Models

    665
    R.H. Lange
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    Pancreatic Hormone Storage Granules: The Role of Metal Ions and Polypeptide Oligomers

    673
    J.E. Pitts, S.P. Wood, R. Horuk, S. Bedarkav and T.L. Blundell
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    On the Molecular Biology of Hagfish Insulin

    683
    S.O. Emdin and S. Falkmer
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  • SECTION XI. INSULIN-RELATED HORMONES
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    Possible Relationships in the Processing, Storage and Secretion of Some Insulin-Related Peptides

    695
    G.G. Dodson, N. Isaacs, R.A. Bradshaw and H.D. Niall
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    Insulin-Like Growth Factors

    703
    R.E. Humbel, R. Andres, C. Ernest, G. Haselbacher, E. Rinderknecht, E.R. Froesch, J. Schwander, H. Walter and J. Zapf
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    Relaxin and Relaxin-Like Peptides in Ovaries of Pregnant Sows and Sharks

    709
    C. Schwabe
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    Structural Studies on Porcine Relaxins and their Biosynthetic Precursors

    719
    H.D. Niall, M. John, R. James, S. Kwok, R. Mercado, G. Bryant-Greenwood, R.A. Bradshaw, M. Gast and I. Boime
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    PRESENTATIONS NOT INCLUDED IN THIS VOLUME

    727
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    LIST OF PARTICIPANTS

    729
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    ABBREVIATIONS

    735
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    SUBJECT INDEX

    739
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    AUTHOR INDEX

    749
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Publishing information
Pages and Images/Illustrations in book
eBook published on:
May 20, 2019
eBook ISBN:
9783111646190
Hardcover published on:
April 1, 1980
Hardcover ISBN:
9783110081565
Edition:
Reprint 2019
Pages and Images/Illustrations in book
Front matter:
18
Main content:
752
Other:
Num. figs.
https://doi.org/10.1515/9783111646190
eBook ISBN: 9783111646190
Hardcover ISBN: 9783110081565
Keywords for this book
Insulin
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