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Progress in Tryptophan and Serotonin Research
Proceedings. Fourth Meeting of the International Study Group for Tryptophan Research ISTRY, Martinsried, Federal Republic of Germany, April 19-22, 1983
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Edited by:
H. G. Schlossberger
, H. Steinhart , W. Kochen , B. Linzen and International Study Group for Tryptophan Research
Language:
English
Published/Copyright:
1984
Topics
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Frontmatter
I -
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Preface
V -
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CONTENTS
VII - OPENING SESSION
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Adolf Butenandt's Work on the Metabolism of Tryptophan
1 -
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Tryptophan, the Heart of the Toxic Peptides from Amanita Mushrooms
13 -
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Forty Years of Trypto-Fun
21 -
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Indoleamine Dioxygenase - a Possible Biological Function
33 - QUALITATIVE AND QUANTITATIVE ANALYSIS OF TRYPTOPHAN AND ITS METABOLITES
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Liquid Chromatography/Electrochemistry Determination of Biogenic Amines: Improved Performance Using Low Dead Volume Multiple Electrode Transducers
45 -
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GLC and HPLC Analysis of Tryptophan, Kynurenine and Related Metabolites
55 -
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Monitoring of Tryptophan Levels in Biological Fluids by HPLC: An Improved Method
63 -
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Rapid Determination of Tryptophan and its Metabolitesalong the Kynurenine Pathway by HPLC
67 -
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HPLC-Analysis of Xanthurenic Acid and its 8-Methyl-Ether
71 -
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Free and Total Tryptophan Microdetermination by an Automated Fluorometric Method
77 -
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Comparison of HPLC and GC-MS Methods for the Determination of Tryptophan and its Indole Metabolites in Biological Samples
83 -
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Pineal Indoles: Their Determination by High Performance Liquid Chromatography and the Influence of Diurnal Variation and Tryptophan Administration on their Level in the Rat
91 -
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Higher-Order Derivative Spectrophotometry for the Quantitative Determination of Tryptophan, Tyrosine and Phenylalanine in Two- and Three-Component Mixtures, Peptides and Proteins
95 -
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The Application of a Spectrofluorometer-Optical- Multichannel Analyzer System to the Determination of Tryptophan
103 -
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Picomole Determination of Tryptophan by Derivatization to 9-Hydroxymethyl-ß-Carboline
107 -
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Determination of Tryptophan in Food after Alkaline Hydrolysis: An Evaluation
111 -
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Colorimetric Determination of Tryptophan in Corn-Cob Mix (CCM)
115 -
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Comparison of Tryptophan Assays for Food Proteins
119 - WORKSHOP: ANALYSIS OF TRYPTOPHAN
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Discussion at the Workshop on "Analysis of Tryptophan"
127 - TRYPTOPHAN AND SEROTONIN: NEUROBIOLOGY
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Tryptophan Transport to the Brain: Newer Findings and Older Ones Reconsidered
145 -
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Tryptophan Availability and Serotonin Synthesis in Rat Brain: Effects of Experimental Diabetes
161 -
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Anatomy and Function of Central Serotoninergic Neurons
173 -
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Serotonin Receptor Binding Sites: Localization and Role in the Brain and Peripheral Tissues
189 -
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Involvement of 5-HT2 (S2)- Receptor Sites in the Serotonin-Induced Activation of Cat Platelets
197 -
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The Regulation of 5-Hydroxytryptamine Release from Superfused Synaptosomes by Tryptophan
201 -
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Selective Increases in High Affinity Tryptophan Transport in Synaptosomes from Different Brain Areas Incubated in Sodium-Free Media
205 -
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Formation and Function of Tetrahydro-ß-Carbolines with Special Reference to their Action on [3H] - Tryptamine Binding Sites
209 -
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Regulations of Serotonergic Neurons Innervating the Basal Ganglia: In vivo Release Studies
217 -
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Blood Platelets as Models for Neurons: Similarities of the 5-Hydroxytryptamine Systems
231 -
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In vivo Metabolism of 14C-5-HT, 14C-5.6-DHT and 14C-5.7-DHT by MAO/COMT/Aldehyde Dehydrogenase in Rat Brain
241 -
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Tryptophan Metabolism in the Pineal Gland
251 -
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Some Physiological Responses and Effects of the Pineal Indoleamine Melatonin
259 -
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Pharmacologic Regulation of Serum N-Acetylserotonin
267 -
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N-Acetyltryptophan: Biochemical and Pharmacological Studies
271 -
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Serotonin, a Major Metabolite of Tryptophan in the Rabbit Retina
275 -
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Effect of 5-Hydroxyanthranilic Acid on Arachidonate Metabolites Function in Platelet Aggregation System
285 - WORKSHOP: CLINICAL AND BEHAVIOURAL EFFECTS OF TRYPTOPHAN
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Introduction to Workshop
291 -
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Tryptophan and Human Sleep: An Analysis of 43 Studies
297 -
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L-Tryptophan in Chronic Insomnia
305 -
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Tryptophan (500 mg) Decreases Subjectively Perceived Sleep Latency and Increases Sleep Depth in Man
311 -
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Further Evidence of the Hypnotic Properties of Tryptophan
315 -
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The Therapeutic Action of Tryptophan in Depression, Mania, and Aggression
321 -
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The Effects of Dietary Tryptophan on Chronic Maxillofacial Pain Tolerance
325 - PATHOLOGY, CLINICAL ASPECTS
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Modulation of Serotonin Receptors by L-Valine in Hepatic Encephalopathy
333 -
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Effect of a B-Vitamin on Tryptophan Metabolism in South African Bantu with Pellagra
339 -
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Studies on the Urinary Excretion of Xanthurenic Acid in Diabetics
347 -
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Urinary Excretion of Xanthurenic Acid and Zinc in Diabetes
355 -
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Studies of the Clinical Importance and Molecular Defect of Hereditary Vitamin B6 Dependent Xanthurenic Aciduria
359 -
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Tryptophan - Nicotinic Acid Pathway in Cardiovascular Diseases
365 -
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The Dependence of Stress Induced Increases in Functional 5HT Activity on Increased Tryptophan Availability: Evidence that in vivo Electrochemistry Monitors 5-Hydroxyindole Release
383 -
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Increased Availability of Tryptophan to the Brain in Stress is not Mediated via Changes in Competing Amino Acids
387 -
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Free and Bound Plasma Tryptophan Levels in Psychiatric Disorders
391 -
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Cerebrospinal Fluid 5HIAA and Tryptophan in Depression and Suicide
397 -
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The Influence of L5-Hydroxytryptophan (L5-HTP) on Clinical and Biochemical Parameters in Depressive Patients
401 -
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Plasma Tryptophan Levels and 5-Hydroxytryptamine Synthesis in the Brain and the Spinal Cord in "Arthritic" Rats
405 -
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Effects of Antirheumatic Drugs and Tricyclic Antidepressants on Total and Free Serum Tryptophan Levels in Arthritic Rats
409 -
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Tryptophan, Serotonin and 5-Hydroxyindoleacetic Acid Levels in Human CSF in Relation to Pain
413 -
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Dynamics of Plasma Tryptophan Following Antimigraine Drugs
417 -
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Comparison of Morphine and Meptazinol Effects on Rat Tryptophan Disposition and Metabolism
425 -
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Decreased Concentrations of Tryptophan and Serotonin in the Brain of Developing Hyperphenylalaninemic Rats - A Contribution to the Understanding of the Metabolic Effects in Phenylketonuria
429 -
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Cofactor Dependency of Serotonin and Catecholamine Biosynthesis in Patients with Atypical Phenylketonuria and Endogenous Depression
437 -
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Tryptophan, 5-Hydroxytryptophan and Dopa Metabolism in the Rat with Experimental Phenylketonuria
443 -
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The Role of Tryptophan Oxidation in Ocular Tissue Damage
449 -
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Tryptophan and Kynurenine in Senile Cataract
469 -
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Urinary 5-Hydroxyindoleacetic Acid and Serum Phénobarbital of Children Suffering from Epilepsy
473 -
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Anticonvulsant Drugs Produce Different Effects on Plasma Tryptophan Concentrations in Epileptic Patients
479 -
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The Role of Metabolism in 3-Methylindole-Induced Acute Lung Injury
483 -
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Beta-Carboline Levels in Blood of Smokers and Non-Smokers
491 -
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The Relationship between Tryptophan, Tryptophan Metabolites and Bladder Cancer
503 -
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Role of Indoleamine 2,3-Dioxygenase in the Defence Mechanism against Tumor Growth
513 -
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The Relationship between Plasma Kynurenine and Indoleamine 2,3-Dioxygenase Activity in the Extrahepatic Tissues
517 -
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L-Tryptophan Metabolism along the Kynurenine Pathway in Human Malignant Melanoma
521 - NUTRITIONAL ASPECTS
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Content and Stability of Tryptophan in Foods
527 -
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Increased Aromatic Amine (Kynurenine) in Dried Fish Meat under Sunlight
535 -
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Tryptophan Requirement of Farm Animals
537 -
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Pattern of Radioactivity from Endogenous 3H-Tryptophan Excreted in the Urine of Fasted or Rats Fed Diets Containing Different Levels of Casein
545 -
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Protein/Carbohydrate Selection in Rats Following Administration of Tryptophan, Glucose or a Mixture of Amino Acids
549 -
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Influence of Tryptophan on Gastric Mucosal Protein Synthesis
553 -
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Tryptophan and Intestinal Secretion
563 -
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Tryptophan Metabolism in Undernourished Developing Rat Brain
567 -
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Effect of Tryptophan on Protein Utilization and Energy Intake of Pigs
571 -
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A High Carbohydrate, Protein-Free Meal, either at Breakfast or in the Evening Does not Alter Plasma Tryptophan to Large Neutral Amino Acid Ratios in Healthy Men
579 -
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Effects of Large Neutral Amino Acids on Tryptophan Transport into the Brain during Development
583 -
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Contribution of Exegenous N15 -Tryptophan to Plasma and Red Blood Cell Tryptophan and Kynurenine in Healthy Humans
587 -
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Carbohydrate Meal Increases Brain 5-Hydroxytryptamine Synthesis in the Adult Rat only after Prolonged Fasting
591 -
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Exogenous Tryptophan: A Study of its Effects on the Levels of Aromatic Amine(s) in Cerebral and Hepatic Tissues in Mice
595 -
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Influence of Excess Leucine Intake on the Conversion of Tryptophan to NAD in Rats Fed Low Protein Diet
599 -
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The Pellagragenic Action of a Dietary Excess of Leucine: Effects of a High-Leucine Diet on Tryptophan Metabolism
603 -
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Effect of Cadmium on some Key Enzymes of Tryptophan - NAD Pathway in Rats in vivo
607 -
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The Influence of Increased Availability of Tryptophan on the Formation of Tryptamine and Serotonin during Early Ontogenesis
613 - TRYPTOPHAN METABOLISM IN MAMMALS
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Tryptophan Metabolism and its Control in Mammalian Liver
625 -
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Tryptophan Metabolism by the Isolated, Perfused Liver and Kidney of Rat (Quantification of the Metabolism by the Compartmental Analysis)
633 -
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Effects of Oestrogens on the Metabolism of Tryptophan Implications for the Interpretation of the Tryptophan Load Test for Vitamin B6 Nutritional Status
637 -
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The Functions and Regulation of Tryptophan Pyrrolase
641 -
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Kynurenine Aminotransferase Activity in Human and other Mammalian Tissues
651 -
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Intracellular Localization and Characterization of 3-Hydroxykynureninase in Human Liver
657 -
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Time-Course of 5-HTP Metabolism in Rabbits: Relevance of Transaminating Pathway
661 -
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Tryptophan Aminotransferase Activity in Rat Liver
665 -
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The Oxygenation of Tryptophan and Indoles with Superoxide Ion and Dioxygen in the Presence of Copper and Ruthenium Catalysts
669 -
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Serotonin- and Melatonin-Dependent Light Emission Induced by Xanthine Oxidase
673 -
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The in vivo Effect of Sodium Fluoride on the Key Enzymes of Tryptophan Metabolism
677 -
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Roles of Active Oxygen and Superoxide Dismutase in Anthranilatnide Hydroxylation and its Derived Phenoxazinone-Like Pigment Formation by Rat Liver Microsomal Monooxygenase System
681 -
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Protective Effect of Tryptophan upon the Influence of N-Methylformamide on the Development, the NAD Synthesis, and the Activity of the Adenosine Diphosphate Ribosyl Transferase of Rat Embryos
685 -
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Induction of Tyrosine Aminotransferase by Tryptophan in Rat Liver
689 - TRYPTOPHAN METABOLISM IN INSECTS
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Tryptophan Metabolism in Drosophila
697 -
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Roles of Active Oxygen and Catalase in the Formation of Phenoxazinone Pigments Catalysed by Manganese Ion
711 -
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Ommochrome-Potassium Urate Complex as Pigment of Red Faeces of Locusta migratoria (Insecta, Orthoptera, Acrididae)
715 -
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Changes in Fluorescence and Size of the Cytoplasmic Granules in the Malpighian Tubules of Drosophila melanogaster Linked with Tryptophan Metabolism
719 -
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Hormonal Control of Pigmentation in Manduca sexta
723 -
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Tryptophan Metabolism and Morphological Color Change in Insects
733 -
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The Structure of Papiliochrome II, the Yellow Wing Pigment of the Papilionid Butterflies
743 -
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Some Chemical Properties of Papiliochrome R
747 - TRYPTOPHAN METABOLISM IN PLANTS AND MICROORGANISMS
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Metabolism of Tryptophan in Pseudomonas aureofaciens
753 -
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Does Tryptophan Side Chain Oxidase from Pseudomonas ATCC 29574 Contain a Quinoprotein?
761 -
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Tryptophan Side Chain Oxidase (TSO) - Structure and Reaction Mechanism
765 -
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Characterization of three Tryptophan Aminotransferases from Candida maltosa
769 -
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Anthranilate Hydroxylase and the Short-Cut-Pathway for the Biosynthesis of Nicotinamide Nucleotides in Aspergillus niger
773 -
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Biosynthesis of Tryptophan Derived Alkaloids in Higher Plants: Enzymati Formation of the Sarpagine-Ajmaline Group
777 -
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Acridone Alkaloid Biosynthesis in Tissue Cultures of Ruta graveolens
785 -
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Isolation and Biological Activities of Diterpene Anthraniloyl and 3-Hydroxyanthraniloyl Peptide Esters from Euphorbia mi Iii
789 -
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New Biological Significance of Indole-Containing Compounds as Initiators or Tumor Promoters in Chemical Carcinogenesis
793 -
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Biosynthesis of Serotonin and Auxin in Seeds of Juglans regia
803 -
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Blepharismone: a Conjugation-Inducing Tryptophan Derivative in the Ciliate Blepharisma
807 -
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Biological Activity of Blepharismone Derivatives - An Approach Towards Biogenesis of the Hormone
815 - TRYPTOPHAN IN PROTEINS AND PEPTIDES
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Advances in the Chemical Modification of Tryptophan in Peptides and Proteins
829 -
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Peptide Bond Cleavage at Tryptophan with Cyanogen Bromide - Mechanism of the Reaction
839 -
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Tryptophan, a Pitfall for the Peptide Chemist
845 -
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Photochemical arid Radiochemical Reactions of Tryptophan: Modification of a Single-Strand Binding Protein from Bacteriophage T4
853 -
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X-Ray Structure Analyses of Tryptophan Derivatives as Models for Stereochemical Aspects of the Toxic Peptides from Amanita Mushrooms
861 -
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AUTHOR INDEX
865 -
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SUBJECT INDEX
869 -
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ABBREVATIONS
889 -
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Backmatter
891
Publishing information
Pages and Images/Illustrations in book
eBook published on:
July 22, 2019
eBook ISBN:
9783111641546
Hardcover published on:
January 1, 1984
Hardcover ISBN:
9783110097603
Edition:
Reprint 2019
Pages and Images/Illustrations in book
Front matter:
19
Main content:
889
Other:
Num. figs.
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