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Nucleic Acids Chemistry
Modifications and Conjugates for Biomedicine and Nanotechnology
-
Edited by:
Ramon Eritja
Language:
English
Published/Copyright:
2025
About this book
This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed. New: expands on DNA nanotechnology and presents the fundamentals and new development of RNA therapeutics including CRISPR/Cas9, RNA editing and mRNA vaccines.
- Novel backbones for therapeutic nucleic acids.
- Lipid-, peptide- and protein-oligonucleotide conjugates.
- Modified DNA nanostructures.
- Aptamers and DNA catalysts.
- RNA therapeutics.
- Novel backbones for therapeutic nucleic acids.
- Lipid-, peptide- and protein-oligonucleotide conjugates.
- Modified DNA nanostructures.
- Aptamers and DNA catalysts.
- RNA therapeutics.
Author / Editor information
Ramon Eritja, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain.
Topics
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Frontmatter
I -
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Preface to the second edition
V -
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Contents
VII -
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List of Contributing Authors
IX -
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1 Methods for the synthesis of oligonucleotides
1 -
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2 Synthesis of oligonucleotides carrying DNA lesions for DNA repair studies
47 -
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3 Synthesis of oligonucleotides carrying modified bases for DNA and protein recognition
87 -
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4 Non-radioactive labeling of oligonucleotides and postsynthetic modification of oligonucleotides
141 -
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5 Nucleic acids triple helices
183 -
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6 Nucleic acids quadruplex
231 -
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7 Advances in therapeutic oligonucleotide chemistry
271 -
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8 Oligonucleotide conjugates
333 -
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9 DNA nanotechnology for drug delivery
365 -
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Index
401
Publishing information
Pages and Images/Illustrations in book
eBook published on:
September 9, 2025
eBook ISBN:
9783111425085
Hardcover published on:
September 9, 2025
Hardcover ISBN:
9783111424682
Edition:
2nd edition
Pages and Images/Illustrations in book
Front matter:
8
Main content:
414
Illustrations:
127
Coloured Illustrations:
16
Tables:
2
Audience(s) for this book
Researchers and professionals in biochemistry, pharmaceutical chemistry, molecular biology and medicine
Safety & product resources
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Manufacturer information:
Walter de Gruyter GmbH
Genthiner Straße 13
10785 Berlin
productsafety@degruyterbrill.com
