Bioactive Five-Membered Heterocycles
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Edited by:
Asit K. Chakraborti
and Bubun Banerjee
About this book
Bioactive Five-Membered Heterocycles provides detailed information on the green synthesis of the structurally diverse pharmaceutically active five-membered heterocycles. It covers both synthesis and biological aspects and highlights the role of five-membered heterocycles in drugs and drug designing. It also includes naturally occurring bioactive five-membered heterocycles.
- State-of-the-art guide on 5-membered heterocycles.
- Indispensable to medicinal chemists.
Author / Editor information
Bubun Banerjee received his Ph.D. degree from Visva-Bharati University, Santiniketan, West Bengal, India. He has nearly ten years of experience in the field of research related to green and sustainable developments. Presently he is working as an assistant professor of chemistry at the Department of Chemistry, Akal University, Talwandi Sabo, Bathinda, Punjab, India. Dr. Banerjee published more than 110 research articles in the internationally renowned journals and authored twenty book chapters; he also co-edited twenty books and guest edited sixteen different special thematic issues of different journals.
Professor Asit K. Chakraborti obtained his M. Sc. degree in 1977 in Organic Chemistry from the University of Burdwan, West Bengal, India being placed first in the first class and Ph. D. degree in Synthetic Organic Chemistry from IACS, Kolkata, India in 1985. After post-doctoral research training in USA in the department of Chemistry, Clemson University, South Carolina, during 1985-1987 and in Medicinal Chemistry at Purdue University, Indiana, USA during 1987-1989 he joined the University of Burdwan as a faculty in the department of Chemistry and served for the period 1990-1994. He joined the department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar (Mohali), Punjab, India as Assistant Professor in 1994 and was elevated to the position of Associate Professor in 1999 and to Professor and Head in 2001. After superannuation from NIPER, Mohali in August 2019 he joined the Department of Chemistry, Indian Institute of Technology-Ropar, Rupnagar, Punjab, India as Visiting Professor and moved to the School of Chemical Sciences, Indian Association for the Cultivation of Science (IACS), Jadavpur, Kolkata, West Bengal, India as Emeritus/DAE Raja Ramanna Fellow. He has guided 41 Ph. D. and 130 Masters’ students, published 187 research papers (with > 14,000 citation with h index of 69), and filed 42 patents (28 granted). He is among the top 2% Indian scientists in the field of organic chemistry according to the independent study of Standford University on World ranking of top 2% Indian scientists and is among the Top Chemistry Scientist 2022 (World Rank 3713; National Rank 31). Prof. Chakraborti received several awards and recognition such as University Gold Medal, Bardhaman Sammilani Gold Medal, ISMAS Eminent Mass-spectroscopist award, Ranbaxy Research Award (Pharmaceutical Sciences), Chemical Research Society of India Silver (2022) & Bronze (2006) Medals, Professor P. K. Bose Memorial Award 2019 of the Indian Chemical Society, Dr. Nitya Anand Endowment Lecture 2021 and Distinguished Lecture Fellowship 2023 in Chemistry of the Indian National Science Academy. He also received the Rajnibhai V. Patel PharmInnova Best Research Guide Awards for the most "Innovative Ph. D. Thesis" during 2017-2018 and 2016-2017 and the most "Innovative MS Thesis" during 2015-2016 and 2014-2015 in "Pharmaceutical Chemistry," Certificate of Appreciation for Ph. D. thesis Advisor of Eli Lilly and Company Asia Outstanding Thesis First Prize Awardee in 2013, 2012, and 2009 and Second Prize Awardee in 2009. He is Fellow of the Royal Society of Chemistry, Cambridge, UK and elected Fellow of Indian Academy of Sciences, Bangalore and Indian National Science Academy, New Delhi and Life Fellow of the Indian Chemical Society. His research interests are in the fields of synthetic organic and medicinal chemistry with thrust in new drug development in tuberculosis, inflammation, and leishmaniasis to develop NMEs through development of novel synthetic methodologies [catalysis (solid-supported protic acids and transition-metal based catalysts, hetero bi-metallic nano-catalysts), C-H activation etc.] in compliance with the green chemistry principles and deriving novel concepts (understanding the molecular level role of acceleration of organic reactions in water and fluorous alcohols, the origin of the organocatalytic potential of ionic liquids etc.).
Topics
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Frontmatter
I -
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Dedicated to Sant Baba Iqbal Singh Ji, Founder Chancellor, Akal University
V -
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Preface
VII -
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Foreword
IX -
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A brief professional profile of Prof. Béla Török
XI -
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Contents
XIII -
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Chapter 1 Naturally occurring bioactive five-membered heterocycles
1 -
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Chapter 2 Photochemically mediated synthesis of five-membered heterocycles
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Chapter 3 Ultrasound-assisted synthesis of five-membered heterocycles
93 -
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Chapter 4 Microwave-assisted synthesis of tetrazoles
123 -
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Chapter 5 Organocatalyzed synthesis of five-membered heterocycles
141 -
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Chapter 6 Solvent-free synthesis of five-membered heterocycles
177 -
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Chapter 7 Sustainable synthesis of bioactive functionalized five-membered heterocycles via flow chemistry
211 -
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Chapter 8 Green synthesis of bioactive pyrroles
243 -
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Chapter 9 Green synthesis of bioactive indoles
283 -
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Chapter 10 Sustainable contemporary methods for the construction of oxazole-decorated heterocycles
315 -
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Chapter 11 Recent advances in the metal-free synthesis of novel isoxazoles and evaluation of their biological activities
341 -
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Chapter 12 Green synthesis of bioactive thiazoles
393 -
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Chapter 13 Green synthesis of bioactive carbazoles
413 -
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Chapter 14 Sustainable contemporary methods for the construction of cyclopentene-decorated five-membered heterocycles
441 -
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Chapter 15 Ascorbic acid-mediated synthesis of five-membered heterocycles
475 -
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Chapter 16 Green synthesis of bioactive imidazo[1,2-a]pyridines
493 -
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Chapter 17 Photon- and electron-mediated alternative synthesis of selenium-decorated five-membered heterocyclic compounds
511 -
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Chapter 18 Synthesis of selenium-containing bioactive five-membered heterocyclic compounds under green conditions: a decade update
541 -
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Chapter 19 Industrial applications of five-membered heterocylces
573 -
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Index
613
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