Home Physical Sciences Chapter 1.2 Advanced hydrogels for biomedical applications
Chapter
Licensed
Unlicensed Requires Authentication

Chapter 1.2 Advanced hydrogels for biomedical applications

  • Sudip Kumar Sinha
Become an author with De Gruyter Brill
Explore this Subject How to publish with us
Advanced Biomedical Composites
This chapter is in the book Advanced Biomedical Composites

Abstract

Hydrogels represent a very promising class of material constituted with networks of cross-linked polymers swelling in water that can be created to exhibit attributes like soft biological tissues. Their capability to mimic tissues’ native extracellular matrix makes them useful for a range of biomedical uses, including drug delivery, cell culture, contact lenses, and even the replacement of native tissue. Numerous groundbreaking studies have been conducted in the last few decades to investigate the interactions between cells and hydrogel matrixes and determine the underlying mechanisms, opening the door for the translation of hydrogel-based therapeutics from the lab to the clinic. Even though this field’s study is expanding, there are still several obstacles preventing sophisticated applications. In this chapter, all kinds of biomedical-grade polymeric hydrogels are methodically examined, with a focus on sophisticated production methods from the standpoint of tissue engineering. Hydrogel synthesis techniques are thoroughly reviewed here, and a comprehensive overview of biopolymer-based hydrogels for biomedical applications, particularly in bone regeneration, wound healing, drug administration, bioimaging, and treatment is provided. Lastly, a summary of the challenges encountered in the sector are offered, along with various schemes for new developments and investigations.

Abstract

Hydrogels represent a very promising class of material constituted with networks of cross-linked polymers swelling in water that can be created to exhibit attributes like soft biological tissues. Their capability to mimic tissues’ native extracellular matrix makes them useful for a range of biomedical uses, including drug delivery, cell culture, contact lenses, and even the replacement of native tissue. Numerous groundbreaking studies have been conducted in the last few decades to investigate the interactions between cells and hydrogel matrixes and determine the underlying mechanisms, opening the door for the translation of hydrogel-based therapeutics from the lab to the clinic. Even though this field’s study is expanding, there are still several obstacles preventing sophisticated applications. In this chapter, all kinds of biomedical-grade polymeric hydrogels are methodically examined, with a focus on sophisticated production methods from the standpoint of tissue engineering. Hydrogel synthesis techniques are thoroughly reviewed here, and a comprehensive overview of biopolymer-based hydrogels for biomedical applications, particularly in bone regeneration, wound healing, drug administration, bioimaging, and treatment is provided. Lastly, a summary of the challenges encountered in the sector are offered, along with various schemes for new developments and investigations.

Chapters in this book

  1. Frontmatter I
  2. Preface V
  3. Contents VII
  4. 1 Materials
  5. Chapter 1.1 Introduction to biomaterials: advances in ceramic and polymer matrix composites 1
  6. Chapter 1.2 Advanced hydrogels for biomedical applications 23
  7. Chapter 1.3 Recent developments of nanocomposites and fabrications for biosensor applications 73
  8. Chapter 1.4 Evolution of metallic dental implants: historical perspective, needs, and application 89
  9. Chapter 1.5 Tribological behavior of specific implant materials for dental applications 107
  10. 2 Design
  11. Chapter 2.1 Patient-specific implant (PSI) design 127
  12. Chapter 2.2 Modeling techniques of bone tissue scaffolds 167
  13. Chapter 2.3 Fundamentals of computational modeling of biomechanics in the musculoskeletal system 195
  14. Chapter 2.4 Computational modeling of bone, muscles, soft tissues, and ligaments 205
  15. Chapter 2.5 Computational modeling of articular cartilage and cell mechanics 213
  16. Chapter 2.6 Experimental and computational analysis for osteoporotic fracture implant failure 233
  17. Chapter 2.7 Computational modeling of fracture implants 239
  18. 3 Manufacturing
  19. Chapter 3.1 Patient-specific implant (PSI) by additive manufacturing 249
  20. Chapter 3.2 Development of artificial skin using composites 273
  21. Chapter 3.3 Development of nerve tissue replacement using composites 297
  22. Chapter 3.4 Manufacturing of advanced prosthetic limbs using composites 343
  23. Index 357
https://doi.org/10.1515/9783111386027-002

Chapters in this book

  1. Frontmatter I
  2. Preface V
  3. Contents VII
  4. 1 Materials
  5. Chapter 1.1 Introduction to biomaterials: advances in ceramic and polymer matrix composites 1
  6. Chapter 1.2 Advanced hydrogels for biomedical applications 23
  7. Chapter 1.3 Recent developments of nanocomposites and fabrications for biosensor applications 73
  8. Chapter 1.4 Evolution of metallic dental implants: historical perspective, needs, and application 89
  9. Chapter 1.5 Tribological behavior of specific implant materials for dental applications 107
  10. 2 Design
  11. Chapter 2.1 Patient-specific implant (PSI) design 127
  12. Chapter 2.2 Modeling techniques of bone tissue scaffolds 167
  13. Chapter 2.3 Fundamentals of computational modeling of biomechanics in the musculoskeletal system 195
  14. Chapter 2.4 Computational modeling of bone, muscles, soft tissues, and ligaments 205
  15. Chapter 2.5 Computational modeling of articular cartilage and cell mechanics 213
  16. Chapter 2.6 Experimental and computational analysis for osteoporotic fracture implant failure 233
  17. Chapter 2.7 Computational modeling of fracture implants 239
  18. 3 Manufacturing
  19. Chapter 3.1 Patient-specific implant (PSI) by additive manufacturing 249
  20. Chapter 3.2 Development of artificial skin using composites 273
  21. Chapter 3.3 Development of nerve tissue replacement using composites 297
  22. Chapter 3.4 Manufacturing of advanced prosthetic limbs using composites 343
  23. Index 357
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 7.10.2025 from https://www.degruyterbrill.com/document/doi/10.1515/9783111386027-002/html
Scroll to top button