Chapter 3 Nanoengineering hydrogels with improved antimicrobial characteristics
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Tahseen Arshad
Abstract
In recent years, hydrogels have secured significant consideration as a result of their extraordinary characteristics in the biomedical field. Researchers have been working on developing hydrogels of biopolymers with the incorporation of different bactericidal substances. Hydrogels possess characteristics such as biodegradability, biocompatibility, enhanced mechanical strength, and therapeutic properties, which made them suitable candidates for use in the domain of biomedicine. Hydrogels provide controlled drug release, wound healing, regulating cell proliferation and inflammatory response, and specific recognition of cell receptors, with improved mechanical strength similar to the extracellular matrix, essential for antibacterial biomaterials. The main emphasis of this section is on the medical applications of nanocomposite hydrogels, as well as the latest activities to overcome their current limitations. An emerging global public health issue is the quick spread of antibiotic resistance in pathogenic microorganisms. Antibiotics used locally might be the reason. Materials must function as the drug delivery method in local applications. The drug delivery mechanism should be biodegradable to meet clinical demand and offer sustained antibacterial activity. Due to its excellent hydrophilicity, unique three-dimensional structure, favorable biocompatibility, and ability to adhere to cells, a hydrogel is considered one of the most effective biomaterials for drug delivery in the field of antimicrobial treatment. In order to address antibiotic resistance, metal nanoparticle-loaded hydrogels were emphasized.
Abstract
In recent years, hydrogels have secured significant consideration as a result of their extraordinary characteristics in the biomedical field. Researchers have been working on developing hydrogels of biopolymers with the incorporation of different bactericidal substances. Hydrogels possess characteristics such as biodegradability, biocompatibility, enhanced mechanical strength, and therapeutic properties, which made them suitable candidates for use in the domain of biomedicine. Hydrogels provide controlled drug release, wound healing, regulating cell proliferation and inflammatory response, and specific recognition of cell receptors, with improved mechanical strength similar to the extracellular matrix, essential for antibacterial biomaterials. The main emphasis of this section is on the medical applications of nanocomposite hydrogels, as well as the latest activities to overcome their current limitations. An emerging global public health issue is the quick spread of antibiotic resistance in pathogenic microorganisms. Antibiotics used locally might be the reason. Materials must function as the drug delivery method in local applications. The drug delivery mechanism should be biodegradable to meet clinical demand and offer sustained antibacterial activity. Due to its excellent hydrophilicity, unique three-dimensional structure, favorable biocompatibility, and ability to adhere to cells, a hydrogel is considered one of the most effective biomaterials for drug delivery in the field of antimicrobial treatment. In order to address antibiotic resistance, metal nanoparticle-loaded hydrogels were emphasized.
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of contributors IX
- Chapter 1 Miscellaneous applications of hydrogels 1
- Chapter 2 An overview of the mechanical behavior of hydrogels 17
- Chapter 3 Nanoengineering hydrogels with improved antimicrobial characteristics 35
- Chapter 4 Stimulus-responsive hydrogel for tissue engineering 49
- Chapter 5 Hydrogel in wound dressing and burn dressing products with antibacterial potential 67
- Chapter 6 Emerging fabrication strategies of hydrogel and its use as a drug delivery vehicle 79
- Chapter 7 Hydrogels for personal care products 103
- Chapter 8 Hydrogels for kidney carcinoma 119
- Index 133
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of contributors IX
- Chapter 1 Miscellaneous applications of hydrogels 1
- Chapter 2 An overview of the mechanical behavior of hydrogels 17
- Chapter 3 Nanoengineering hydrogels with improved antimicrobial characteristics 35
- Chapter 4 Stimulus-responsive hydrogel for tissue engineering 49
- Chapter 5 Hydrogel in wound dressing and burn dressing products with antibacterial potential 67
- Chapter 6 Emerging fabrication strategies of hydrogel and its use as a drug delivery vehicle 79
- Chapter 7 Hydrogels for personal care products 103
- Chapter 8 Hydrogels for kidney carcinoma 119
- Index 133
