Preface

Chapters in this book

1. Frontmatter I
2. Preface V
3. Contributors VII
4. Contents XV
5. I. Synthesis And Assembly
6. A scheme for the intracellular assembly of human fibrinogen 3
7. Evidence that platelet and plasma fibrinogen have the same A-alpha chain gene product 15
8. Fibrinopeptide A and the phosphorylation of fibrinogen 23
9. II. Structure and Function
10. Size and shape of the fibrinogen molecule: crystalline forms of native and modified human fibrinogen 35
11. The C-terminal polymerisation domain of fibrinogen 47
12. γ- Chain Crosslinking Of Fibrin At Dd-Trans Contact 55
13. Soluble fibrin contains fibrin polymers of different molecular weight. Ultracentrifugation studies at 37°C 61
14. Relationship of final thickness of fibrin fibers to maximal rate of assembly and to fibrinopeptide B release 69
15. III. Congenital Variants
16. Fibrinogen New York 1: The structural, functional, and genetic defects and an hypothesis of the role of fibrin in the regulation of coagulation and fibrinolysis 79
17. Fibrinogen Pontoise - a genetically abnormal fibrinogen with defective fibrin polymerisation but normal fibrinopeptide release 91
18. Fibrinogen Milano I: Abnormal fibrin polymerization related to a carboxy-terrainal defect of the γ-chain (γ-330 Asp Val) 97
19. Fibrinogen "Bergamo I" (Λα 16 Arg - Cys): Alternative methods for structure elucidation 103
20. Screening small plasma samples by HPLC for abnormalities of fibrinopeptide release 111
21. Iv. Fibrin(ogen) And Fibrinolysis
22. On the role of fibrin in the fibrinolytic system 121
23. Isolation and characterisation of plasmic degradation products of fibrinogen by high-performance liquid chromatography 137
24. The acceleration of tissue-type plasminogen activator (t-PA)-mediated activation of plasminogen by fibrinogen cyanogen bromide fragments is species specific 145
25. Role of fibrin polymerization in fibrinolysis: Comparison between polymerisable and unpolymerisable fibrins in the potentiating effect of plasminogen activation by tissue-type plasminogen activator (tpA) 153
26. Role of fibrin and its degradation products in the activation of plasminogen by streptokinase and urokinase 159
27. V. Interactions With Cells
28. The role of fibrinogen in platelet aggregation 175
29. Platelet-associated fibrinogen: Conformational change of fibrinogen induced by its adsorption to platelet-surface 185
30. Migration of cultured endothelial cells in response to fibrinogen 193
31. Characteristics of the interactions of fibrinogen and soluble fibrin with cultured endothelial cells 203
32. Mechanism of fibrin-induced disorganisation of cultured human endothelial cells 211
33. The fibrinogen: red cell interaction and its influence on blood rheology 219
34. Haemorheologic effects of plasmin and thrombininduced fibrinogen derivatives: An in vitro study 229
35. Binding of human fibrinogen to streptococci and its role in streptococcal pathogenicity 239
36. VI. Assays To Fibrin(ogen) Fragments And Their Use
37. Discrimination between fibrin and fibrinogen by a monoclonal antibody against a synthetic hexapeptide representing the amino-terminus of the alpha-chain of fibrin 253
38. A new enzyme immunoassay of fibrin(ogen) degradation products in plasma using a monoclonal antibody 261
39. Fibrin(ogen) degradation products. Determination using a monoclonal anti D neo antibody. Advantages in clinical investigation 271
40. A monoclonal antibody, specific for human fibrinogen and fibrinopeptide A-containing fragments. Its application in an enzyme-immunoassay for fibrinogen degradation products, suitable for use in plasma 279
41. A monoclonal antibody against the CNBr-peptide F-CB3 of the Aα-chain of human fibrinogen 297
42. Clinical aspects of fibrin formation and fibrinolysis measured with monoclonal antibodies against D-dimer 303
43. Fibrinogen derivatives in acute stroke 313
44. VII. Fibrin(ogen) And Disease Pathology
45. Triggering of the extrinsic blood coagulation system 325
46. Extravascular fibrin formation and fibrinolysis in a model of inflammation accompanying cellular hypersensitivity 337
47. Extra-vascular fibrin deposition in cellular hypersensitivity - the role of T lymphocyte-macrophage interactions 347
48. Fibrinolytic studies in disorders of connective tissue 357
49. Soluble fibrin/fibrinogen related antigen in human intima in relation to atherogenesis 363
50. Fibrinogen as a possible risk factor for IHD in the Caerphilly study 371
51. VIII. Appendix: Data On Fibrinogen
52. Fibrinogen amino acid sequences 381
53. Author Index 389
54. Subject Index 391
55. Backmatter 397