Contraceptive use of LH-RH agonists

Kapitel in diesem Buch

1. Frontmatter I
2. Opening remarks V
3. Opening remarks VII
4. Contents IX
5. Physiological basis for clinical use of LH-RH and its analogues 1
6. Hypothalamic control of gonadotropin secretion and ovarian function 13
7. Induction of ovulation in amenorrhea infertile women with pulsatile administration of gonadotropin releasing hormone 25
8. Effects of different substituents in the A-ring of estradiol on its potency in sensitizing pituicytes to gonadotropin releasing hormone 33
9. Present status of LH-RH analog chemistry 43
10. Pharmacology of GnRH analogues 51
11. Binding sites for LH-RH in the human — does LH-RH exert extrapituitary actions in man? 61
12. Influence of LH-RH and des-Gly¹⁰ [D-Ala⁶]-LH-RH ethylamide on the biosynthesis of hCG in placental tissue culture 69
13. The pharmacologic profile of [(ImBzl)-D-His⁶,Pro⁹-NEt]-LH-RH (ORF 17070), an LH-RH agonist 81
14. Reversible pharmacologic castration of the female: implications for endometriosis, contraception and ovulation induction 93
15. Metabolism and pharmacokinetics of LH-RH agonists 105
16. Studies on controlled release systems for LH-RH analogues 123
17. Comparative reproductive pharmacology of LH-RH agonist and antagonist: contraceptive, therapeutic and safety aspects 135
18. Comparative non-human primate studies with LH-RH analogues 175
19. Long-term suppression of ovulation in the stumptailes macaque by active immunization against LH-RH or by LH-RH agonist administration 189
20. LH-RH agonists in the male: basic and clinical studies 209
21. A new approach to male contraception using combined androgen and GnRH analog treatment 221
22. LH-RH analog therapy of precocious puberty 229
23. Treatment of prostatic cancer with LH-RH analogues and control of therapy by cytology and DNA cytophotometry 239
24. Clinical experience (up to 40 months) with the LH-RH agonist Buserelin in the therapeutic approach to prostatic cancer 259
25. Antigonadal properties of LH-RH agonists: therapeutical applications in human 269
26. Contraceptive use of LH-RH agonists 283
27. LH-RH analogs and luteal function of the rhesus monkey 295
28. The effects of an LH-RH agonist on the premenstrual syndrome: a preliminary report 307
29. Discontinous intranasal application of the LH-RH analogon Buserelin in combination with an oral progestin in healthy female volunteers 321
30. Reversible down-regulation of pituitary-ovarian function induced by repetitive LH-RH agonist administration as a new approach for treatment and study of endometriosis in the human 337
31. The treatment of endometriosis with LH-RH agonists 349
32. Concluding remarks 355
33. List of First-mentioned Contributors 357