MECHANISM OF INDUCTION OF SYNTHESIS OF SERUM AMYLOID P-COMPONENT (SAP) BY MOUSE HEPATOCYTES IN CULTURE

Chapters in this book

1. Frontmatter I
2. PREFACE V
3. CONTENTS IX
4. INTRODUCTORY LECTURE
5. PROGRESS IN PLASMA PROTEINS RELATED TO INFLAMMATION 3
6. SECTION I. INTERLEUKINS
7. THE BIOLOGICAL EFFECTS OF PURIFIED AND RECOMBINANT HUMAN INTERLEUKIN-1 17
8. ARE THERE DEFECTS IN THE PRODUCTION OF INTERLEUKIN 1 IN DISEASE 27
9. "NEGATIVE" ACUTE PHASE PROTEINS:- AN INTERLEUKIN 1 INDEPENDENT MECHANISM? 37
10. PROSTACYCLIN PRODUCTION FROM VASCULAR ENDOTHELIUM IS ENHANCED BY INTERLEUKIN 1 41
11. EFFECTS OF DRUGS ALTERING ARACHIDONIC ACID METABOLISM ON INTERLEUKIN 1 RELEASE FROM MONOCYTE-LIKE CELLS 43
12. MURABUTIDE INDUCED PRODUCTION OF NON PYROGENIC INTERLEUKIN 1 BY HUMAN MONOCYTES AND RABBIT MACROPHAGES 47
13. DOES PROTRACTED IL1 PRODUCTION CAUSE A DEPRESSION OF CELL MEDIATED IMMUNITY? 55
14. STABLE E ROSETTES : MARKER OF ACTIVATED HUMAN T-LYMPHOCYTES 59
15. PRODUCTION, PURIFICATION AND BIOLOGICAL ACTIVITIES OF NATURAL HUMAN INTERLEUKIN 2 63
16. INTERLEUKIN 2 (IL2) PRODUCTION BY LYMPHOCYTES OF HUMAN BREAST CANCER PATIENTS 77
17. PROTHYMOCYTES IN MOUSE FETAL LIVER PRODUCE INTERLEUKIN-2 83
18. SECTION II. AMYLOID PROTEINS
19. ISOLATION AND PHYSICOCHEMICAL CHARACTERISTICS OF HUMAN SERUM AMYLOID P. COMPONENT FROM NORMAL AND ACUTE PHASE SERA 89
20. SERUM AMYLOID P COMPONENT (SAP) AND HEMOSTASIS: A CONTINUING EVALUATION 99
21. MECHANISM OF INDUCTION OF SYNTHESIS OF SERUM AMYLOID P-COMPONENT (SAP) BY MOUSE HEPATOCYTES IN CULTURE 105
22. REACTIVITY OF HUMAN SERUM AMYLOID P PROTEIN (SAP) WITH CONCANAVALIN A 117
23. A NEW BINDING SPECIFICITY FOR SERUM AMYLOID P COMPONENT AND ITS PRACTICAL APPLICATIONS 125
24. STRUCTURE AND FUNCTION OF SAA 129
25. SERUM AMYLOID A PROTEIN - A SENSITIVE INFLAMMATION MARKER 139
26. SAA AS A MARKER OF INFLAMMATORY DISEASE 145
27. CLINICAL USEFULNESS OF SERUM AMYLOID A AND C-REACTIVE PROTEIN MEASUREMENTS IN INFLAMMATORY DISORDERS: A COMPARATIVE STUDY 153
28. IMMUNONEPHELOMETRIC SAA MEASUREMENT 157
29. SECTION III. OTHER HUMAN ACUTE PHASE PROTEINS
30. DOES HUMAN C-REACTIVE PROTEIN CIRCULATE IN COMPLEXED FORM? EQUILIBRIUM CHROMATOGRAPHY AND DIALYSIS STUDIES 165
31. EVALUATION OF A QUANTITATIVE LATEX ASSAY FOR CRP DETERMINATION BY LASER NEPHELOMETRY: RESULTS OF A COLLABORATIVE STUDY 169
32. ALPHA 1-ANTITRYPSIN AND HAPTOGLOBIN IN NORMAL AND ALLERGIC RESPONSES 175
33. THE MOLECULAR VARIANTS OF ALPHA 1-ACID GLYCOPROTEIN: STUDY OF THE GLYCOSYLATED, DIMERIC, POLYMERIC, AND ALBUMIN-COMPLEX FORMS 183
34. FIBRONECTIN FRAGMENTS ACT AS PROMOTERS OF IMMUNOGLOBULIN CRYOPRECIPITATION 195
35. FIBRONECTIN LEVEL IN AMNIOTIC FLUID 201
36. THE HUMAN KALLIKREIN - KININOGEN - SYSTEM 205
37. PROTEASE ACTIVITIES IN THE CYTOSOL OF BREAST TUMORS 217
38. SERUM PROTEIN PROFILE EVOLUTION DURING MODERATE MALNUTRITION 223
39. SECTION IV. ANIMAL ACUTE PHASE PROTEINS
40. BIOCHEMICAL CHARACTERISTICS OF ACUTE PHASE PROTEINS IN THE RAT 231
41. SYNTHESIS OF TWO RAT ACUTE-PHASE REACTANTS: ALPHA-1-ACID GLYCOPROTEIN AND C3 BY HEPATOCYTES CO-CULTURED WITH A LIVER EPITHELIAL CELL 243
42. EFFECTS OF 17-ß-OESTRADIOL, 17-α-ETHYNYLOESTRADIOL, 5-α-DIHYDROTESTOSTERONE AND TURPENTINE-OIL ON THE SYNTHESIS OF C3 AND ALPHA-1-ACID GLYCOPROTEIN IN THE RAT 247
43. PRODUCTION OF ACUTE-PHASE PROTEINS BY HEPATOCYTES MAINTAINED IN CO-CULTURE 253
44. BIOSYNTHESIS AND SECRETION OF HAPTOGLOBIN BY CHICKEN EMBRYO HEHAIOCYTt PRIMARY CULTURE 261
45. THE BROWN NORWAY DEFICIENT RAT AS A TOOL FOR THE STUDY OF THE INVOLVEMENT OF THE KININ SYSTEM IN SOME PHYSIOLOGICAL PROCESSES 265
46. TRANSFERRIN AND ALPHA 2-MACROGLOBULIN-I ARE CIRCULATING ACUTE-PHASE REACTANTS IN THE MOUSE 275
47. A COMPARATIVE STUDY ON THE PHYSICO-CHEMICAL PROPERTIES OF HUMAN, RABBIT AND RAT C-REACTIVE PROTEIN AND SERUM AMYLOID P-COMPONENT 293
48. SERUM AMYLOID P COMPONENT IN THE ASSESSMENT OF ARTHRITIS ACTIVITY IN AUTOIMMUNE MRL/1pr/1pr MICE 297
49. THE EFFECTS OF DIFFERENT DRUGS UPON THE LEVEL OF SERUM AMYLOID P COMPONENT IN AUTOIMMUNE MRL lpr/lpr MICE 303
50. SECTION V. CONNECTIVE MATRIX AND INFLAMMATORY PROCESSES
51. THE EXTRACELLULAR MATRIX AND THE INFLAMMATORY PROCESS 311
52. STRUCTURE AND FUNCTION OF CONNECTIVE TISSUE PROTEOGLYCANS 327
53. ISOLATION AND CHARACTERIZATION OF FIBRONECTIN FROM MOUSE PLASMA 337
54. TYPE V COLLAGEN: HETEROGENEITY IN DIFFERENT TISSUES 343
55. TYPE VI COLLAGEN AND INFLAMMATION 357
56. BASEMENT MEMBRANES AND TUMORAL INVASION IN THE MAMMARY GLAND 363
57. FIBROBLASTS AND FIBROCYTES 369
58. CYTOSKELETAL AND CYTOCONTRACTILE FEATURES OF MYOFIBROBLASTS 375
59. COLLAGEN METABOLISM IN THE AORTA OF SPONTANEOUSLY HYPERTENSIVE RATS: VARIATIONS IN ENZYME ACTIVITIES ACCORDING TO BLOOD PRESSURE AND AGE 387
60. COLLAGEN METABOLISM IN THE HEART OF SPONTANEOUSLY HYPERTENSIVE RATS: VARIATIONS IN ENZYME ACTIVITIES AT DIFFERENT AGES 393
61. CELL-CELL AND CELL-MATRIX INTERACTIONS IN NORMAL AND CIRRHOTIC LIVER 399
62. LIGHT AND ELECTRON MICROSCOPIC IMMUNOLOCALIZATION OF FIBRONECTIN AND TIPE I COLLAGEN IN ADULT RAT HEPATOCYTES DURING PRIMARY CULTURE 411
63. SINUSOIDS AND THE DISSE SPACE IN PATIENTS WITH LIVER DISEASES 417
64. ORIGIN OF COLLAGENS AND FIBRONECTIN IN NORMAL AND FIBROTIC LIVER 433
65. MEASUREMENT OF SERLM PROCOLLAGEN TYPE III N-TERMINAL PROPEPTIDE IN PATIENTS WITH ALCOHOLIC LIVER DISEASE 443
66. THE SCHISTOSOME EGG GRANULOMA AS A MODEL OF CELL-MEDIATED INFLAMMATION, SYNTHESIS AND DEGRADATION OF CONNECTIVE TISSUE MATRIX 449
67. FIBROUS RESORPTION IN SCHISTOSOMAL GRANULOMA 461
68. ANTIBODY TO COLLAGEN CB-PEPTIDES, ALPHA 2-CB(3,5): a marker of type I collagen breakdown 473
69. THE EFFECT OF MALOTILATE IN AN EXPERIMENTAL MODEL OF HEPATIC FIBROSIS INDUCED BY HETEROLOGOUS SERUM IN THE RAT 477
70. DEVELOPMENT OF FIBROSIS IN HEPATIC ALVEOLAR ECHINOCOCCOSIS: A SEQUENTIAL STUDY IN MICE INFECTED WITH ECHINOCOCCUS MULTILOCULARIS 491
71. INTRAALVEOLAR FIBROSIS: A REVERSIBLE FORM OF PULMONARY FIBROSIS 501
72. DISTINGUISHING PATTERNS OF ALVEOLITIS AND FIBROSIS IN HUMAN LUNG DISEASE 507
73. PANCREATIC CONNECTIVE MATRIX CHANGES IN CHRONIC PANCREATITIS 521
74. SECTION VI. IMMUNOMODULATION
75. MONOCLONAL ANTIBODY TARGETING FOR CANCER IMMUNOTHERAPY 529
76. IMMUNOSUPPRESSIVE PROPERTIES OF MURAMYL PEPTIDES 543
77. THE MULTIPLE ACTIVITIES OF INTERFERON GAMMA 551
78. PURINE METABOLISM AND IMMUNOMODULATION OF MONOCYTE FUNCTIONS 571
79. ISOPRINOSINE (INOSIPLEX): AN IMMUNOLOGICAL AND CLINICAL REVIEW 579
80. IMUTHIOL^® 591
81. IMMUNOMODULATION OF MACROPHAGE FUNCTIONS BY A TRIPEPTIDE (TKP) DERIVED FROM IgG 599
82. PHOSPHOLIPIDS AND MEMBRANE PHENOMENA INVOLVED IN THE RELEASE OF MEDIATORS OF ANAPHYLAXIS. MODULATION BY S-ADENOSYL-L-HOMOCYSTEINE AND ITS STRUCTURE ANALOGS 607
83. EFFECT OF THE IMMUNOMODULATOR RU 41740 ON THE PROLIFERATION OF CULTURED MOUSE EMBRYO FIBROBLASTS 621
84. EVALUATION OF THE THYMUS ROLE IN THE LH GENETIC HYPERTENSION BY THYMOSTIMULIN (TP-1) 625
85. TWO IN VITRO EFFECTS OF 40 639 RP IN IMMUNITY MEDIATED CELLS 631
86. VARIOUS IMMUNOMODULATING EFFECTS OF L-METHIONINE IN VITRO 635
87. SECTION VII. LECTINS AND BIOLOGICAL ACTIVITIES
88. IDENTIFICATION OF LECTIN - LIKE BACTERIAL ADHESINS BY IMMUNOAFFINOELECTROPHORESIS 641
89. LECTIN-INDUCED AGGLUTINATION OF MICROORGANISMS IN URODELAN AMPHIBIAN EGG JELLY 647
90. FIBRONECTIN AS A MODEL OF MULTIFUNCTIONAL LECTIN 653
91. MODULATION OF GLYCOSYLATION OF RAT ALPHA 1-ACID CLYCOPROTEIN BY PHENOBARBITAL 661
92. STUDY OF THE SPECIFICITY OF A RAT BRAIN EXTRACT LECTIN 667
93. VARIATIONS IN THE PROPORTIONS OF MICROHETEROGENEOUS FORMS OF HUMAN ALPHA 1-ACID GLYCOPROTEIN IN ALCOHOLIC CIRRHOSIS 673
94. ASSAY OF PHA MITOGENICITY ON HUMAN LYMPHOCYTES AFTER ELECTRO-BLOTTING 679
95. AUTHOR INDEX 683
96. SUBJECT INDEX 687
97. Backmatter 695