Determination of the Degree of Desialylation for Orosomucoid and Alpha₁, Antitrypsin. Application to Rheumatoid Polyarthritic Sera

Chapters in this book

1. Frontmatter I
2. Preface V
3. Contents VII
4. Section I . The Inflammatory Response
5. Progress in Plasma Proteins: Hallmarks of Health and Markers of Disease 1
6. Plasma Proteins Implicated in the Inflammatory Response 21
7. Acute Inflammatory Process 33
8. The Inflammatory Response 45
9. Relationships between Acute Non-Specific Inf lamination and Non-Specific Defense Mechanisms of the Host 49
10. The Role of Thrombocytes in Inflammation 57
11. Section II. Acute Phase Reactants
12. Clinical Usefulness of C Reactive Protein Measurement 69
13. Control Proteins of the Alternative Complement Pathway In Vivo Correlates of In Vitro Function 89
14. Plasma Fibronectin, its Biochemical and Biological Properties and its Pathological Changes in Man 99
15. Interaction between C-Reactive Protein (CRP) and Platelets 111
16. Interactions between CRP and Mononuclear Cells 131
17. Clinical Usefulness of Orosomucoid Determination 139
18. Alpha₁ Acid Glycoprotein - Structure, Genetics and Biological Significance 159
19. Alphai₁-Antitrypsin Structure and Genetics 171
20. Affinity-Immunodeletion (AID) Isoelectric Focusing on Ultra-Thin Gels and Staining with Silver Diamine Applied to the Marker Proteins of Inflammation 185
21. A Survey of the Measurement, Distribution of Values and Phenotypes of the Haptoglobins 197
22. Recent Findings on the Biological Role of Haptoglobin in Rats 209
23. Biochemical Aspects of Complement Activation 215
24. The Acquired Abnormalities of the Complement System in the Acute or Chronic Inflammatory Response 231
25. Acute Phase Reactant Protein Profiles in Cancer: An Approach to Deciphering their Message 239
26. Plasma Protein Profile: A Model of Data for Interpretation with Special Reference to Inflammatory Conditions 253
27. Section III. Malnutrition and the Immune Response
28. Protein-Calorie Malnutrition-Clinical Biochemical and Immunological 277
29. Complement, Orosomucoid, Transferrin, Retinol Binding Protein and Prealbumin in Malnutrition 341
30. Cellular and Humoral Immunity in Malnutrition 347
31. Immune Deficit in Kwashiorkor 355
32. Inhibition of Cell-Mediated Immunity by Serum Abnormalities in Protein-Calorie Malnutrition 369
33. Host Resistance in Malnutrition 381
34. Usefulness of Prealbumin as Nutritional Indicator 405
35. Section IV. Posters.
36. A. Acute Phase Reactants in Neonates
37. A Comparative Study of the Sequential and Coupled Determination of CRP and Orosomucoid during Neonatal Infections 417
38. CRP and Neonatal Sepsis 421
39. Characterization of a C2 Derived Oligopeptide with Biologic Activity 423
40. Direct Quantitation of the Complement C3 Split Product C3d in Plasma in Immunopathological Disorders 424
41. Variations of Orosomucoid Levels in New-Born Twins 427
42. Complement Levels in Infants of Diabetic Mothers over the First Month of Life 429
43. B. Protein Status in Clinical States
44. Protein-Status and Malnutrition, Preliminary Results of a Prospective Study of 177 Patients 437
45. Research of Relationship between Protein and Folic Acid Deficiencies 438
46. The Measurements of Plasma Proteins in Patients with nutritional Deficiency 439
47. Value of Plasma Prealbumin in the Early Recognition of Protein-Energy Malnutrition in Sahelian Children 440
48. Visceral and Muscular Proteins in Anorexia Nervosa: An Example of Severe Malnutrition in Industrialized Countries. Effects of Renutrition 442
49. C. Protein-Calorie Malnutrition and the Immune Response
50. Effects of Protein-Calorie Malnutrition on the Cell- Mediated Immune Response in Mice 447
51. Effects of Early Under- and Over-Nutrition on the Immune Response in Mice 450
52. D. Inflammatory Proteins in Patients with Cancer
53. Plasma Transferrin Level: A Preoperative Prognosis Indicator in Esophageal Cancer Patients 455
54. Usefulness of a Protein Profile as an Indicator for a Gastrostomy in Patients with Advanced Head and Neck Cancer 457
55. Acute Phase Reactant Proteins and Cancer 460
56. Plasmapheresis in Cancer Patients and Acute Phase Reactant Proteins 462
57. Prognostic Value of the Macrophage Component of an Inflammatory Reaction Induced by Skin Abrasion in Cancer Patients 465
58. Nutritional Markers in Advanced Large Bowel Cancer 467
59. Effects of Acute Phase Reactant Proteins on PHA-Induced Lymphocyte Blastogenesis 469
60. Effects of Acute Phase Reactant Proteins on Monocyte Chemotaxis in Vitro 471
61. E. Protein Changes in Other Clinical States
62. Evaluation of Inflammation Proteins, Cardiac Enzymes and Myoglobin in Myocardial Infarcts 477
63. Human Serum Perchlorosoluble Glycoproteins in Myocardial Infarct 480
64. Elevated C-Reactive Protein Levels in Sarcoidosis Patients 483
65. Determination of Plasma Fibronectin Concentration in Pulmonary and Circulatory Failure 486
66. Protein, Alpha₁ Antitrypsin, Lysozyme in Bronchoalveolar Lavage Liquid in Case of Sarcoidosis 489
67. Macrophage Phagocytic Activity and Lysozyme Concentration in Bronchoalveolar Lavages 491
68. Determination of Human Serum Complement Using the Hemolytic Radial Immunodiffusion Micromethod daring Ventilatory Tests of Allergenic Provocation in Asthmatics 493
69. Inflammation Markers in Patients with Pulmonary Pathology 496
70. Usefulness of C-R P /C4 - 1 Index of Detection and Prognosis of Septic States in the Burn Patients 497
71. Assessment of Appropriate Laboratory Measurements to Measure Crohn's Disease Activity 503
72. Assessment of Appropriate Laboratory Measurement to Measure Ulcerative Colitis Activity 505
73. Diagnostic and Prognostic Value of the Plasma Variations of Prealbumin and Transferrin in the Post-Operative Period of Gastrointestinal Tract Surgery - Preliminary Results 507
74. Serum C-Reactive Protein Assay in Renal Transplantation 509
75. Relation between the Quantity of Serum Lysozyme and the Amount of Succinatedehydrogenase (SDH) and Alpha-Glycerophosphate- Dehydrogenase (alpha-GDPH) on Activated Lymphocytes Membranes as a Possible Index of the Immune Response after Human Renal Transplantation 511
76. Study of Some Markers of Inflammation (C Reactive Protein, Haptoglobin, Orosomucoid) in Chronic Inflammatory Articular Rheumatic Diseases 513
77. Levels of Serum C9 Complement Factor in Various Chronic Inflammatory Articular Rheumatic Diseases 516
78. Modifications of "Inflammatory Proteins" (Transferrin, Orosomucoid, Coeruloplasmin, Alpha-l-Antitrypsin in Human Gonadotropin Induced Ovulation 518
79. Changes of Distribution of Glycosylated Forms of Human Orosomucoid and Alpha-2-HS Glycoprotein during Inflammation and Pregnancy: Study by Isoelectric Focusing and Crossed Immuno-Affinity Electrophoresis 520
80. Variation of C Reactive Protein in Serum Following Severe Skull Trauma 524
81. Studies on some Blood Proteins in Medullary Patients 528
82. The Prostaglandin Induced Acute Phase Response and its Failure in Scleroderma 535
83. F. Acute Phase Reactants in Rodents
84. Serum Amyloid P Component in the Rat: Isolation, Characterization and Original Features 541
85. Transcortin (CBG) Actitivities, Endogenous Corticosterone Levels and other Serum Parameters in the Course of the Acute Inflammatory Reaction of the Rat 544
86. Secretion of 3 Proteins during Experimental Inflammation in Rats 547
87. Identification of Intracellular Acute Phase Proteins in the Liver of Mice by Crossed Immunoelectrophoresis 550
88. Studies on the Mechanism of the Prostaglandin Induced Acute Phase Response; its Failure in Endotoxin Tolerant Animals 552
89. G. Proteinase Inhibitors
90. Inhibition of Formation of the Human Amplification C3 Convertase by Fluid Phase Polycations 557
91. Determination of the Degree of Desialylation for Orosomucoid and Alpha₁, Antitrypsin. Application to Rheumatoid Polyarthritic Sera 558
92. Proteinase Inhibitors Controlling Biologie Activity of Lymphoid Tissue Cells 561
93. Binding of Alpha-l-Antitrypsin Specific Antibodies to Human Lymphocytes: A Flow Cell Microfluorometry Study 563
94. Suppression of Antibody-Dependent Lymphocyte Mediated Cytotoxicity by Human Alpha-2 Macrogobulin 565
95. H. Methodology
96. Protein Evaluation of Populations in Intertropical Regions 569
97. Immunophelometric Quantitation of C.R.P. - Importance of Samples Storage 573
98. Pre Albumin Titration Using a Rate Nephelometer. Critical Study. Applications in Nutrition and Oncology 575
99. Plasma Fibronectin: Its Dosage in Clinical Biology 579
100. Quantitative Immunoelectrophoretic Methods 582
101. Protein Profile in Surgical Intensive Care 586
102. Author Index 591
103. SUBJECT INDEX 595
104. Backmatter 609